Clinical study of Yifei moxibustion on COPD based on NFκB/TGF-β1/Smad2 signaling pathway
Objective To investigate the effect of Yifei moxibustion on chronic obstructive pulmonary disease(COPD)and its effect on nuclear factor kappa-B(NF-κB)/transforming growth factor-β1(TGF-β1),and the regulatory role of TGF-β1/human signal transduction molecule 2(Smad2)signaling pathway.Methods Totally 120 COPD pa-tients admitted to the First Affiliated Hospital of Henan University of Chinese Medicine were randomly divided into three groups,40 cases in each group.Western medicine group was treated with western medicine inhalation,traditional chi-nese medicine(TCM)group was treated with Bufei Yishen decoction at the same time,and Yifei moxibustion group was treated with Yifei moxibustion at the same time.Pulmonary function,6-minute walking distance(6MWD),number of acute exacerbations,dyspnea score,COPD assessment scale score and clinical response rate were compared among the three groups.The levels of NFκB/TGF-β1/Smad2 pathway related inflammatory factors were detected before and after treatment.Results After intervention,the lung function index and 6MWT index of Yifei moxibustion group were better than those of TCM group,and TCM group was better than western medicine group(P＜0.05).After treatment,the number of acute exacerbations,dyspnea score and chronic obstructive pulmonary disease evaluation scale scores in Yifei moxibustion group were lower than those in TCM group,and TCM group were lower than western medicine group(P＜0.05).The clinical effective rate of Yifei moxibustion group was higher than that of TCM group,and TCM group was higher than western medicine group(P＜0.05).After treatment,the levels of NFκB/TGF-β1/Smad2 pathway re-lated inflammatory factors in Yifei moxibustion group were lower than those in TCM group,and TCM group were lower than western medicine group(P＜0.05).Conclusion Yifei moxibustion can effectively improve the pulmonary function and prognosis of COPD patients,and improve the clinical effective rate,and its mechanism may be related to inhibiting the level of inflammatory factors related to NFκB/TGF-β1/Smad2 pathway.
Yifei moxibustionMoxibustionChronic obstructive pulmonary diseaseInflammationIntegration of tradi-tional chinese and western medicineMechanism of action
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