Effects of dexmedetomidine combined with paroxib sodium on inflammatory factors,sedation and intestinal barrier function in patients with mechanical ventilation sepsis
Objective To investigate the effects of dexmedetomidine combined with paroxib sodium on inflammatory fac-tors,sedation and intestinal barrier function in patients with mechanical ventilation sepsis.Methods Selected 120 pa-tients with sepsis undergoing mechanical ventilation from June 2018 to June 2019 in Zhengzhou People's Hospital.Ac-cording to the random digital table method,the patients were divided into two groups with an average of 60 patients in each group.The patients in the control group were treated with paroxib sodium analgesia,while the observation group combined with dexmetomidine for analgesic treatment on the basis of the control group.The contents of tumor necrosis factor(TNF-α),interleukin-1(IL-1)and IL-6 were determined respectively.The changes of bispectral index(BIS),pulse oxygen saturation(SpO2),diastolic blood pressure(DBP),systolic blood pressure(SBP),mean arteri-al pressure(MAP)and heart rate(HR)before and 30 min after sedation were compared.The extubation time,respira-tory recovery time,recovery time and adverse reaction were also counted.The plasma enteric fatty acid binding protein(I-FABP)and D-lactic acid concentration in peripheral venous blood were analyzed by ELISA kit,and the probabili-ty of multiple organ insufficiency syndrome(MODS)and sequential organ failure(SOFA)scores were analyzed.Results With the increase of treatment days,TNF-α,IL-1 and IL-6 inflammatory factors decreased in the two groups,and the observation group decreased significantly compared with the control group(P＜0.05).All the indexes of HR,SBP,DBP,MAP,SpO2 and BIS in the two groups were decreased after drug therapy(P＜0.05).After sedation,the extubation time,respiratory recovery time,and eye opening time were shorter in the observation group than of the control group,and the probability of side effects was significantly higher in the observation group than of the control group(P＜0.05).With the increase of treatment days,the concentration of I-FABP and D-lactic acid decreased gradually,and the observation group decreased significantly compared with the control group,and the SOFA score and the probability of MODS in the observation group were lower than those of the control group(P＜0.05).Conclusion Dexmedetomidine combined with paroxib sodium can significantly reduce the inflammatory factors in pa-tients,and the sedation effect is better to protect the intestinal barrier function of patients,which is worthy of clinical promotion.
DexmedetomidineParoxib sodiumMechanical ventilation sepsisInflammatory factorSedationIntestinal barrier function
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