The value of prostate-specific antigen homeomer 2,percentage and prostate health index in differentiating benign and malignant prostate diseases
Objective Experimental study on Prostate-specific antigen isoform 2(Prostate-specific antigen isoform 2,p2PSA),Prostate-specific antigen isoform 2 percentage(p2PSA％)and prostate health index(prostate Health Index,PHI)in the value in differentiating benign and malignant prostate diseases.Methods Taking 80 patients with prostate diseases diagnosed by needle biopsy admitted to Henan Provincial People's Hospital from March 2021 to May 2023 as the study object,all patients with prostate diseases were divided into two groups according to disease diagnosis.The first group was benign prostate disease group(benign group),with a total of42 patients;the other group was malignant pros-tate disease,namely prostate cancer group(malignant group),with a total of 38 patients.4 mL of venous blood of all subjects was collected after fasting for more than 8 h,and total prostate-specific antigen(t-PSA),free prostate-specific antigen(f-PSA),and p2PSA levels in serum was tested,and the levels of p2PSA and PHI are calculated,recorded and analyzed for data to evaluate the value of each indicator in differentiating benign and malignant prostate diseases.When comparing the specificity of each serum marker for the diag-nosis of prostate cancer,the control variable method was used to determine the comparative advantage or disadvantage of other markers by fixing the values of some markers.Results The levels of t-PSA,p2PSA,p2PSA％,and PHI indica-tors in the serum of patients in the benign prostate disease group were significantly lower than those of the prostate cancer group,and the difference between the two groups was significant(P＜0.05);the levels of f-PSA indicators between the two groups were not statistically significant(P＞0.05).It can be known from the ROC curve that the AUCs of t-PSA,f-PSA,p2PSA,p2PSA％,and PHI in determining prostate cancer are 0.64,0.58,0.75,0.83,and 0.86 re-spectively.In addition,through the control variable method,it was concluded that p2PSA and PHI have greater advanta-ges in specificity and sensitivity compared with other indicators.It can be seen that the AUC of p2PSA％and PHI is lar-ger and more effective in identifying prostate cancer.Conclusion Among the various markers for identifying benign and malignant prostate diseases,p2PSA,p2PSA％and PHI,especially PHI,have better results than the traditional PSA de-tection method,and can significantly improve the sensitivity and specificity,and reduce the number of puncture biopsies and misdiagnosis.The joint detection of p2PSA and PHI will provide an important reference for the diagnosis,treatment and prognosis of clinical prostate cancer.
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