Relationship between sTg and cervical lymph node metastasis in patients with DTC after thyroidectomy and 131I treatment
Objective To explore the relationship between local lymph node metastasis and stimulated thyroglobulin(sTg)after 131I treatment for differentiated thyroid cancer(DTC).Methods A retrospective analysis of the clinical da-ta of 157 patients with differentiated thyroid cancer who underwent 131I 100-150mCi treatment in the Department of Nu-clear Medicine of the First Affiliated Hospital of Zhengzhou University from September 2016 to September 2020.Patients who were treated with 131I for 4 to 5 months later stopped taking levothyroxine sodium tablets for 3 to 4 weeks and were diagnosed with cervical lymph node metastasis.Spearman correlation analysis was performed on the sTg value and the number and diameter of cervical metastatic lymph node lesions;x2 test was performed for the difference between different regions of recurrent cervical lymph nodes,gender between sTg-positive and sTg-negative groups,and the difference between the recurrence sites of patients(one or both sides of the neck);t test was performed on the number of lesions detected between the sTg-positive and sTg-negative groups.Results In the stimulated state,among the 157 patients with cervical lymph node metastasis,area Ⅲ and Ⅳ were the common metastatic sites(P＜0.05),and unilateral me-tastases were more common than bilateral metastases(P＜0.05).There is a linear relationship between sTg and the number and diameter of cervical metastatic lymph nodes(r=0.517,P＜0.05;r=0.361,P＜0.05);there was a statistically significant difference between the patient's gender,number of lesions,and location of lesions in patients with sTg positive and sTg negative(P＜0.05).Conclusion sTg can be used as a tumor marker for patients with DTC after thyroidectomy and 131I treatment,and there are differences be-tween sTg-positive and-negative in gender,number of lesions,and location of lesions.But sTg negative cannot rule out no metastatic disease in the body.
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