分化型甲状腺癌131I治疗后颈部转移淋巴结与刺激状态下甲状腺球蛋白之间关系
Relationship between sTg and cervical lymph node metastasis in patients with DTC after thyroidectomy and 131I treatment
李祥周 1李彦鹏 1温鑫 1闫志华 1程兵1
作者信息
- 1. 郑州大学第一附属医院核医学科,郑州 450003
- 折叠
摘要
目的 探讨分化型甲状腺癌(differentiated thyroid cancer,DTC)术后131I治疗后局部淋巴结转移与刺激状态下甲状腺球蛋白(stimulated thyroglobulin,sTg)之间关系.方法 回顾性分析2016年9月至2020年9月于郑州大学第一附属医院核医学科行131I 100～150 mCi治疗157例的分化型甲状腺癌患者临床资料,所有患者131I治疗4～5月后停服左甲状腺素钠片3～4周均确诊颈部淋巴结转移病灶.统计患者颈部转移淋巴结个数及直径、颈部淋巴结分区、sTg、性别等临床资料.对sTg值与颈部转移淋巴结病灶个数及直径之间行Spearman相关分析;对于颈部淋巴结复发不同区域之间、sTg阳性与sTg阴性组间患者性别、患者病灶复发部位(颈部单侧或双侧)间差异行x2检验;对sTg阳性与sTg阴性组间患者所检出病灶个数行t检验.结果 在刺激状态下,157例颈部淋巴结转移患者中,Ⅲ区与Ⅳ区是常见转移部位(P＜0.05),颈部单侧转移较双侧转移多见(P＜0.05).sTg与颈部转移淋巴结个数及直径之间成线性关系(分别为r=0.517、P＜0.05;r=0.361、P＜0.05);sTg阳性与sTg阴性患者中性别、病灶数目、病灶复发部位之间差别有统计学意义(P＜0.05).结论 sTg可作为DTC术后131I治疗后肿瘤标志物,能反映DTC患者131I治疗后颈部复发淋巴结个数与大小;且sTg阳性与sTg阴性患者之间性别、病灶数目及病灶部位之间有差别;但sTg阴性,不能排除体内无转移病灶.
Abstract
Objective To explore the relationship between local lymph node metastasis and stimulated thyroglobulin(sTg)after 131I treatment for differentiated thyroid cancer(DTC).Methods A retrospective analysis of the clinical da-ta of 157 patients with differentiated thyroid cancer who underwent 131I 100-150mCi treatment in the Department of Nu-clear Medicine of the First Affiliated Hospital of Zhengzhou University from September 2016 to September 2020.Patients who were treated with 131I for 4 to 5 months later stopped taking levothyroxine sodium tablets for 3 to 4 weeks and were diagnosed with cervical lymph node metastasis.Spearman correlation analysis was performed on the sTg value and the number and diameter of cervical metastatic lymph node lesions;x2 test was performed for the difference between different regions of recurrent cervical lymph nodes,gender between sTg-positive and sTg-negative groups,and the difference between the recurrence sites of patients(one or both sides of the neck);t test was performed on the number of lesions detected between the sTg-positive and sTg-negative groups.Results In the stimulated state,among the 157 patients with cervical lymph node metastasis,area Ⅲ and Ⅳ were the common metastatic sites(P＜0.05),and unilateral me-tastases were more common than bilateral metastases(P＜0.05).There is a linear relationship between sTg and the number and diameter of cervical metastatic lymph nodes(r=0.517,P＜0.05;r=0.361,P＜0.05);there was a statistically significant difference between the patient's gender,number of lesions,and location of lesions in patients with sTg positive and sTg negative(P＜0.05).Conclusion sTg can be used as a tumor marker for patients with DTC after thyroidectomy and 131I treatment,and there are differences be-tween sTg-positive and-negative in gender,number of lesions,and location of lesions.But sTg negative cannot rule out no metastatic disease in the body.
关键词
分化型甲状腺癌/甲状腺球蛋白/甲状腺球蛋白抗体/131I/颈部淋巴结Key words
Differentiated thyroid carcinoma/Thyroglobulin/Thyroglobulin antibody/131I/Cervical lymph node引用本文复制引用
基金项目
河南省重点研发与推广专项(科技攻关)项目(212102310176)
出版年
2024
NETL
NSTL
万方数据