A study on predictive value of combined early pregnancy homocysteine levels and peripheral blood lymphocyte subsets for unexplained recurrent spontaneous abortion
Objective To explore the predictive potential of early pregnancy homocysteine levels alongside peripheral blood lymphocyte subsets for unexplained recurrent spontaneous abortion(URSA).Methods We enrolled 172 pregnant women with a history of URSA admitted to the Fetal Protection Ward of the Second Affiliated Hospital of Zhengzhou Uni-versity covering the period from September 2020 to March 2023.All patients were tested for homocysteine and peripheral blood lymphocyte subsets within 24 hours after admission.The study population was categorized into a miscarriage group and a continuing pregnancy group based on whether patients experienced a miscarriage before 28 weeks of gestation.Logis-tic multiple regression analysis was utilized to ascertain factors that exerted an impact on pregnancy outcomes among indi-viduals experiencing unexplained recurrent miscarriage.The efficacy of these factors in predicting miscarriage was assessed through receiver operating characteristic(ROC)curve analysis.Results Among 172 pregnant women,87 had abortion and 85 had ongoing pregnancy.Multivariate analysis showed that homocysteine(HCY),NK cells,B cells and the per-centage of Th/Ts were all associated with pregnancy outcomes in women with unexplained recurrent miscarriage(P＜0.05).ROC curve analysis indicated that the AUC values of homocys-teine,NK cells,B cells and Th/Ts ratio in early pregnant URSA patients for predicting pregnancy outcomes were 0.781(95％CI:0.713～0.849),0.684(95％CI:0.604～0.764),0.711(95％CI:0.633～0.788),0.710(95％CI:0.634～0.785),0.873(95％CI:0.822～0.925),respectively.Conclusion The detection of homocysteine and peripheral blood lymphocyte subsets in early pregnancy is valuable for predicting pregnancy outcomes of URSA patients,and the combined detection has higher predictive efficiency.
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