Application value of PCSK6 combined with BNP in renal insufficiency complicated with heart failure
Objective To investigate the expression level of proprotein converting enzyme subtilysin 6(PCSK6)in chronic renal insufficiency(CRI)complicated with heart failure(HF),and the value of the combined diagnosis of PCSK6 and brain natriuretic peptide(BNP)in CRI complicated with HF.Methods A total of 129 patients with CRI who were hospi-talized in the renal department of two 3 A grade hospitals in Henan Province from June 1,2023 to January 31,2024 were selected,including 53 patients with simple CRI and 76 patients with heart failure(HF).General clinical data,BNP,cre-atinine,urea,uric acid,cystatin C,glomerular filtration rate(eGFR)and other laboratory test indicators,left ventricular ejection fraction,E/A value,ventricular septal thickness,left ventricular posterior wall thickness,and other cardiac func-tion parameters were collected.The serum PCSK6 concentration of the two groups was compared by ELISA.The correlation be-tween serum PCSK6 and BNP was analyzed by Spearman corre-lation.ROC curve analysis of the diagnosis of serum PCSK6 combined with BNP in the prediction of CRI combined with HF.Results PCSK6 and BNP in HF group with CRI were higher than those in simple CRI group,and the difference was statistically significant(P＜0.05).According to Spearman correlation analysis,serum PCSK6 was positively correlated with BNP(r=0.440,P＜0.001).According to ROC curve analysis,the AUC of serum PCSK6 combined with BNP in the diagnosis of CRI combined with HF was 0.884,higher than that of PCSK6(AUC=0.822)and BNP(AUC=0.835).Conclusion Serum PCSK6 is related to BNP.Serum PCSK6 combined with BNP has a good predictive value for the diagnosis of CRI combined with HF,and serum PCSK6 is expected to be a new marker of CRI combined with HF.
NETL
NSTL
万方数据
