Expression of serum IL-17A,NLR,TGF-βand its diagnostic value in children with Crohn's disease at active stage
Objective To explore the expression and predictive value of interleukin-17A(IL-17A),neutrophil to lymphocyte ratio(NLR)and transforming growth factor β(TGF-β).On the active stage of Crohn's disease in chil-dren.Methods Totally 40 children with Crohn's disease who were diagnosed and treated in the Department of Gastroen-terology of the Affiliated Children's Hospital of Zhengzhou University from July 2019 to August 2022 were selected.The total number of hospitalizations was 85.According to the Children's Crohn's Disease Activity Index(PCDAI),they were divided into remission group(41 times),mild activity group(25 times)and moderate activity group(19 times),com-pare the serum levels of IL-17A,NLR,and TGF-β in each group,and using receiver operating characteristic(ROC)curves analyzed the predictive value of serum IL-17A,NLR,and TGF-β for the active phase of Crohn's dis-ease.Results Comparsion of serum IL-17A,NLR,TGF-β in children with Crohn's disease of different PCDAI and controls:moderate and severe activity group(134.42±35.35,4.05±1.93,53.63±15.90)＞mild activity group(111.56±36.67,2.80±1.00,32.68±10.77)＞remission group(95.12±24.15,1.93±0.65,23.66±7.86)＞control group(83.30±22.93,1.28±0.45,18.30±6.64),which were statistically significant.ROC curve analysis shows that,the area under the curve(AUC)of IL-17A,NLR,TGF-β,and their combined prediction of active phase in children with Crohn's disease were 0.717,0.781,0.838,and 0.893,the Joden index was 0.683,0.488,0.612 and 0.669 respectively,and the corresponding sensitivity and specificity at the best critical value point were:IL-17A was 70.5％,68.3％,NLR was 65.9％,82.9％,TGF-β63.6％,97.6％,80.5％and 86.4％respectively.Conclusion Children with Crohn's disease during the active phase exhibit high expression of serum IL-17A,NLR,and TGF-β,the combination of serum IL-17 A,NLR,and TGFβcan effectively predict the active phase of children with Crohn's disease.
Interleukin 17ANeutrophil to lymphocyte ratioTransforming growth factor βChildrenCrohn's diseaseActivity period
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