Analysis of risk factors for brain dysfunction in patients with sepsis caused by pulmonary infection
Objective To investigate the risk factors of brain dysfunction in patients with sepsis caused by pulmonary in-fection.Methods Totally 142 patients with sepsis due to pulmonary infection admitted from Mar.2020 to Sept.2022 were divided into sepsis induced brain dysfunction(SIBD)group(77 cases)and non-SIBD group(65 cases)according to whether SIBD occurred.General data and laboratory indicators of the two groups were compared.Independent risk factors for SIBD were analyzed by logsitic regression.Results The proportion of patients with septic shock,mechanical ventilation,acute respiratory distress syndrome,length of ICU stay,SOFA score and APACHEII score in SIBD group were higher than those in non-SIBD group(P＜0.05).Hemoglobin in SIBD group was lower than that in non-SIBD group,urea nitrogen,serum creatinine,prothrombin international ratio,procalcitonin,S100β protein and neuron specif-ic enolase were higher than those in non-SIBD group(P＜0.05).OFA score(OR=1.583,95％CI:1.234～5.281),GCS score(OR=2.181,95％CI:2.358～9.731),S100β protein(OR=1.324,95％CI:1.253～4.732)levels were an independent risk factor for SIBD in patients with sepsis due to pulmonary infection(P＜0.05).Conclusion SOFA score,GCS score and S100β protein level are the main risk factors for predicting SIBD.Strengthe-ning the dynamic monitoring of these indicators may be an effective measure to prevent the occurrence and development of SIBD.
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