Value of platelet-derived growth factor receptor alpha in prognosis of gastric cancer and correlation with tumor immunity
Objective To investigate the effect of platelet-derived growth factor receptor alpha(PDGFRB)in gastric cancer on the prognosis of gastric cancer patients and to analyze its correlation with tumor immunity to provide new ideas for gastric cancer immunotherapy.Methods Gene expression profile datasets,mutation data and relevant clinical infor-mation of gastric cancer patients were downloaded from public database for subsequent analysis.Firstly compared the ex-pression and prognosis of PDGFRB in different tumors.Also,explored the relationship between PDGFRB and immune checkpoints,tumor mutational load(TMB)and immune microenvironment.And these features were used to construct a nomogram.Exploring the pathways significantly enriched in PDGFRB high and low expression groups using GSEA en-richment analysis.Results PDGFRB was highly expressed in gastric cancer patients and could be an independent prog-nostic risk factor for gastric cancer.The PDGFRB high expression group had a lower TMB,higher immune score and stromal score,and higher immune checkpoint expression.Signaling pathways such as the intestinal immune network for IgA production were significantly enriched in the PDGFRB high expression group.PDGFRB high expression group might respond better to immunotherapy.Conclution PDGFRB could be a potential molecular marker to predict the prognosis of gas-tric cancer and provide new ideas for immunotherapy of gastric cancer.
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