Relationship between serum RBP4 and α2-MG and microvascular complications of type 2 diabetes mellitus and clinical outcome after treatment
Objective To analyze the relationship between serum retinol binding protein 4(RBP4),α2-macroglobulin(α2-MG)and type 2 diabetes microvascular complications(DMA)and clinical outcomes after treatment.Methods A total of 180 patients with T2DM admitted to the First People's Hospital of Pingdingshan from June 2015 to June 2018 were selected,and divided into non-DMA group(97 cases)and DMA group(83 cases)according to whether they had DMA.The serum RBP4 and α2-MG levels of the non-DMA group and the DMA group were compared.Logistic regression model was used to analyze the influencing factors of DMA occurrence in T2DM patients.The clinical outcomes after DMA treatment were followed up for 5 years,and the patients who had adverse outcomes were included in the adverse group(35 cases),and the rest of the patients were included in the good group(39 cases).The serum RBP4 and α2-MG levels of the good group and the adverse group were compared.Receiver operating characteristic curve(ROC)was established to evaluate the predictive value of ser-um RBP4 and α2-MG for clinical outcomes after DMA treatment.Results Compared with the non-DMA group,the age,smoking history percentage,HbA1c,fasting blood glucose,RBP4 and α2-MG levels of the DMA group were increased,and the T2DM course was prolonged(P＜0.05).Logistic regression model showed that age,smoking history,T2DM course,fast-ing blood glucose,RBP4,α2-MG were influencing factors for DMA occurrence in T2DM patients(P＜0.05).Compared with the good group,the serum RBP4 and α2-MG levels of the adverse group increased(P＜0.05).ROC curve showed that the best cut-off points for serum RBP4 and α2-MG to predict adverse clinical outcomes after DMA treatment were 80.68 mg/L and 1.37 mg/mL respectively,and the AUCs of single and combined detection of both were 0.777,0.700,0.862 respectively.Conclusion High serum RBP4 and α2-MG levels are risk factors for DMA occurrence,and combined detec-tion of both has a high predictive value for clinical outcomes after DMA treatment.
Type 2 diabetesMicrovascular complicationsRetinol binding protein 4α2-macroglobulinClinical out-come
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