Effects of stereotactic radiotherapy and whole brain radiotherapy on short-term efficacy in lung cancer with brain metastases
Objective To analyze the effects of stereotactic radiotherapy(SRT)and whole brain radiotherapy(WBRT)on the short-term efficacy,pain,serum matrix metalloproteinase-9(MMP-9),insulin-like growth factor-1(IGF-1)and neurocognitive function in lung cancer with brain metastases.Methods Totally 81 patients with lung cancer compli-cated with brain metastases admitted to General Hospital of Pingmei Shenma Medical Group from December 2020 to De-cember 2022 were selected and divided into SRT group(n=40)and WBRT group(n=41)according to different treat-ment methods.SRT group.was treated with SRT,and WBRT group was given WBRT.The short-term efficacy,NRS score and serum MMP-9 and IGF-1 levels before and after radiotherapy and neurocognitive function and quality of life before radiotherapy,after radiotherapy and at 3 months after radiotherapy were compared between the two groups.Results The objective remission rate in SRT group was higher than that in WBRT group(P＜0.05),but there was no statistically significant difference in disease control rate between the two groups(P＞0.05).After radiotherapy,the NRS score and levels of serum MMP-9 and IGF-1 in the two groups were reduced compared with those before radiotherapy(P＜0.05),and the score and levels in SRT group were lower than those in WBRT group(P＜0.05).After radiotherapy and at 3 months after radiotherapy,the MMSE score,MoCA score and QLQ-C30 score in SRT group were significantly enhanced compared with those before radiotherapy(P＜0.05),and the scores at 3 months after radiotherapy were higher than those after radiotherapy(P＜0.05),but there were no statistical differences in WBRT group compared with those be-fore radiotherapy(P＞0.05).Conclusion SRT is more beneficial than WBRT to improve the short-term efficacy,re-lieve the pain,and reduce the levels of serum MMP-9 and IGF-1 in patients with lung cancer and brain metastases,and the former one is more helpful to enhance the neurocognitive function and quality of life of patients.
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