Analysis of factors associated with effects of concomitant use of cerebrolysin and alteplase on cerebral infarction and hemorrhagic transformation of cerebral infarction
Objective To investigate the effect of simultaneous use of Cerebrolysin and alteplase in the treatment of cere-bral infarction and to analyze the factors affecting hemorrhagic transformation(HT)in cerebral infarction.Methods Prospectively selected 498 patients with cerebral infarction admitted to our hospital from September 2021 to September 2023 as the study object,all patients received both Cerebrolysin and atteplase,analyzed the efficacy of Cere-brolysin and atteplase for cerebral infarction,the change of functional rating scale(FCA)before and after treatment and the occurrence of HT by binary logistic regression.Results After treatment,347(69.68％)patients recovered,84(16.87％),58(11.65％)and 9(1.81％).The paired sample t-test results showed that the FCA score after treat-ment was significantly higher than that before treatment,and the difference was statistically significant(P＜0.05).Af-ter 14d of treatment,HI 1 was 26(5.22％),HI 210(2.01％),and PH 18(1.61％),the total HT was 44(8.84％);and the FCA score in the HT group was lower than that in the non-HT group(P＜0.05).Binary logistic regression analysis showed that atrial fibrillation,antiplatelet medication,BMI,baseline blood glucose,baseline NIHSS score,and onset to thrombolytic therapy were all risk factors for HT(P＜0.05).Conclusion The simultaneous treat-ment of Cerebrolysin and alteplase for cerebral infarction have good efficacy and effectively improved the functional out-come of patients,and the incidence of HT is low.AF fibrillation,antiplatelet medication,BMI,baseline blood glucose,systolic blood pressure after 24 h,baseline NIHSS score,and time from onset to thrombolytic therapy are all risk factors for HT.Clinical attention shouldbe strengthened.
NETL
NSTL
万方数据
