Relationship between severity of acute anteruor uveitis and level of helper T cell related factors
Objective To investigate the relationship between the severity of acute anterior uveitis(AAU)and the level of helper T cell(Th)related cytokines.Methods A prospective case-control study design was used.A total of 40 patients with AAU admitted to the ophthalmology department of the Second Affiliated Hospital of Zhengzhou University from May 2021 to May 2022 were collected,and another 30 patients who underwent physical examination during the same period were selected as the control group.The levels of interleukin-4(IL-4),interleukin-9(IL-9),interleukin-17(IL-17)and transforming growth factor-β1(TGF-β1)in peripheral blood of the patients were detected by ELISA,and the differences of the above indexes between the two groups were compared.The severity of AAU disease was measured accord-ing to EIU score,and the relationship between the levels of IL-4,IL-17,IL-9 and TGF-β1 and EIU score in AAU patients was analyzed.Results The levels of IL-4,IL-9,IL-17 and TGF-β1 in AAU group were higher than those in control group(P＜0.05).IL-4,IL-9,IL-17 and TGF-β1 were positively correlated with EIU score(r=0.426,0.544,0.596,0.514,P=0.006,0.000,0.000,0.001).The EIU score of AAU patients was 0-3 in 12 cases,4-6 in 15 cases,and 7-9 in 13 cases.There was a positive correlation between IL-4 and IL-9(r=0.418,P=0.007),but no significant correlation between IL-4 and IL-17 and TGF-β1(r=0.293,0.265,both P＞0.05).There was no significant correlation between IL-9 and IL-17 and TGF-β1(r=0.129,0.161,both P＞0.05),and no significant correlation between IL-17 and TGF-β1(r=0.280,P＞0.05).Conclusion The changes of Th-related cytokines are closely related to the occurrence and development of AAU,and IL-4 and IL-9 exhibita correlation that may play an im-portant role in the pathogenesis of AAU.
Aacute anterior uveitisHelper T cellsCytokinesAutoimmune disease
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