Effect of whole-course nutritional support therapy on curative effect and PG-SGA score in patients with local advanced cervical cancer treated with radiotherapy and chemotherapy
Objective To analyze the effects of whole-course nutritional support therapy on acute radiation response,tolerance and curative effect in patients with cervical cancer.Methods Totally 112 patients with locally advanced cervi-cal cancer admitted to Affiliated Cancer Hospital of Zhengzhou University from June 2020 to December 2022 were select-ed and divided into groups according to whether they received nutritional support therapy or not.56 cases receiving sim-ultaneous chemoradiotherapy alone were taken as the basic group,and 56 cases receiving full nutritional support therapy on the basis of simultaneous chemoradiotherapy were taken as the study group.The efficacy,tolerance and radiation re-sponse of the two groups were compared.Results The effective rate of clinical intervention in the research group was 89.28％,which was higher than 64.28％in the basic group(P＜0.05);the interruption rate and the total days of ra-diotherapy in the study group were 17.85％and(62.31±7.46)d,respectively,lower than that in the basic group,and the number of chemotherapy completion times was(4.98±0.51),higher than that in the basic group,with statisti-cal significance(P＜0.05).The total incidence of thrombocytopenia,acute gastrointestinal reaction and acute radiation cystitis in the study group was 21.42％,25.00％and 28.57％,respectively,which were lower than those in the basic group(P＜0.05).The PG-SGA score of the study group after intervention was 5.13±0.44,which was lower than that of the basic group(P＜0.05).Conclusion The use of whole-course nutritional support therapy during chemotherapy and radiotherapy in patients with LACC can not only reduce the acute radiation reaction of patients,but also significantly improve the efficacy,treatment compliance and quality of life,and ensure that radiotherapy can be completed according to the plan,which has significant clinical application value and is worth promoting.
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