Correlation analysis between H-type hypertension complicated with acute cerebral infarction and carotid intima-media thickness
Objective To analyze the correlation between H-type hypertension complicated by acute cerebral infarct(ACI)and carotid intima-media thickness(CIMT).Methods Totally 90 patients with ACI in Nanyang Central Hos-pital from January 2021 to December 2023 were selected and divided into group A(H-type hypertension combined with ACI group).group B(hypertension combined with ACI group)and group C(ACI group alone)according to their homo-cysteine(Hcy)level and whether they had hypertension.Another 30 healthy people who came to Nanyang Central Hos-pital for physical examination at the same period were selected as group D,and Hcy,soluble intercellular adhesion mole-cule-1(sICAM-1)and interleukin-6(IL-6)of the four groups were detected.IL-6,interleukin-8(IL-8),monocyte chemotactic protein 1(MCP-1),chitinase protein 40(YKL-40),monocyte chemotactic protein 1(MCP-1)level was measured by color Doppler ultrasonography,and the correlation between Hcy level and CIMT was analyzed.Results The levels of sICAM-1,IL-6,IL-8,MCP-1 and YKL-40 in groups D,C and B were higher than those in group A,the difference between groups was statistically significant(P＜0.05).The levels of sICAM-1,IL-6,IL-8,MCP-1 and YKL-40 in groups D and C were higher than those in group B,the difference between groups was statisti-cally significant(P＜0.05).The levels of sICAM-1,IL-6,IL-8,MCP-1 and YKL-40 in group D were higher than those in group C,the difference between groups was statistically significant(P＜0.05).The Hcy level in groups D,C and B was higher than that in group A,and the CIMT was higher than that in group A,the difference between groups was statistically significant(P＜0.05).The Hcy level in groups D and C was higher than that in group B,and the CIMT was higher than that in group B,the difference between groups was statistically significant(P＜0.05).The Hcy level of group D was higher than that of group C,and the CIMT was higher than that of group C,the difference be-tween groups was statistically significant(P＜0.05).Pearson correlation analysis showed that there was a positive corre-lation between Hcy level and CIMT in ACI group(P＜0.05).Conclusion Elevated Hcy level is an important factor leading to CIMT thickening.Hcy level can be used as an important indicator to evaluate the prognosis of patients with H-type hypertension combined with ACI.Reducing Hcy level can improve the prognosis of patients,delay the progres-sion of carotid atherosclerosis,and reduce the risk of ACI.
NETL
NSTL
万方数据
