Effect of montelukast sodium combined with caroxonate sodium sulfonate on children with anaphylactoid purpura
Objective To investigate the therapeutic effect of montelukast sodium combined with carbosulfonate sodium sulfon-ate in the treatment of children with anaphylactoid purpura and the effects on the levels of serum cytokines,suppressor of cyto-kine signaling 3(SOCS3)and galactose deficient-IgA1(Gd-IgA1).Methods A total of 94 children with anaphylactoid purpura admitted to Chinese Medicine Hospital of Puyang from August 2021 to December 2022 were selected and divided into two groups according to different treatment methods.The two groups were given the same basic treatment.47 cases treated with montelukast sodium were taken as the control group,and 47 cases treated with montelukast sodium combined with carox-ulfonate sodium were taken as the study group.The therapeutic effect,serum cytokine and Gd-IgA1 levels,SOCS3 expres-sion levels,clinical symptoms resolution time and adverse reactions were compared between the two groups.Results The total effective rate of the study group was 97.87％,which was higher than that of the control group(85.11％)(P＜0.05).The mRNA levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),Gd-IgA1 and SOCS3 in two groups were not statistically significant before treatment(P＞0.05),but decreased after treatment.The mRNA levels of TNF-α,IL-6,Gd-IgA1 and SOCS3 in the study group after treatment were(12.11±5.24)ng/mL,(18.96±5.84)pg/mL,(0.09±0.01)U and(1.48±0.19)lower than those in the control group(P＜0.05).After treatment,the remission time of skin purpura,rash,arthralgia and abdominal pain in the study group was(4.79±1.76)d,(5.44±1.38)d,(5.01±1.69)d and(3.47±1.06)d,which were shorter than those in the control group(P＜0.05).The incidence of adverse reac-tions in the study group was 17.02％,higher than that in the control group(14.89％),but the difference was not statisti-cally significant(P＞0.05).Conclusion Montelukast sodium combined with caroxulfonate sodium sulfonate in the treat-ment of children with anaphylactoid purpura can obtain significant curative effect,and has obvious significance in relieving inflammation and improving symptoms in children.
Children allergic purpuraMontelukast sodiumCarbazol sodium sulfonateCurative effect
NETL
NSTL
万方数据
