Efficacy and safety of Tenon's posterior capsule triamcinolone injection in treatment of optic neuritis in children
Objective To observe the clinical effect and safety of Tenon subcapsular injection of triamcinolone in the treatment of optic neuritis in children.Methods A total of 60 children(120 eyes)with optic neuritis admitted to Zhengzhou Seventh People's Hospital from June 2018 to June 2023 were randomly divided into an observation group re-ceiving Tenon injection after triamcinolone and a control group receiving systemic glucocorticoid steroids.Mecobalamine,citicoline sodium capsules and compound anisodine injection were given subcutaneous injection at the superficial tempo-ral artery in each group.Baseline characteristics were similar between the two groups.Clinical effiicacy,visual evoked potential(VEP),visual field,photosensitivity,CFF-red,green and yellow values were statistically analyzed after 1 month and 3 months of treatment in the two groups.Results After 1 month of treatment,the total effective rate of the observation group(96.66％)was better than that of the control group(78.33％)(P＜0.05).VEP examination showed that the P100 wave amplitude of the observation group was(7.58±3.54)μV,higher than that of the control group[(6.78±3.18)μV](P＜0.05),and the latency of the observation group was(91.58±13.82)ms,lower than that of the control group[(97.20±15.66)ms](P＜0.01).The average visual field defect in the observation group was(0.54±0.33)dB,lower than that in the control group[(0.63±0.28)dB](P＜0.01).The average photosensitivity of observation group was(22.46±3.86)dB,which was higher than that of control group[(24.87±4.17)dB](P＜0.01).The mean value of CFF-red,green and yellow[(29.64±6.94,31.66±8.42,32.64±7.68)Hz]in observation group was higher than that in control group[(28.76±5.12,29.65±3.22,30.62±7.12)Hz].The difference between groups was statistically significant(P＜0.01).Conclusion Post Tenon subcapsular in-jection of triamcinolone acetonide is safe and effective in the treatment of pediatric optic neuritis,with no adverse reac-tions,and is suitable for promotion and application in grassroots hospitals.
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