Effects of topiramate combined with sodium valproate on clinical efficacy and serum leptin and APN levels in children with epilepsy
Objective To analyze the clinical efficacy of topiramate combined with sodium valproate in the treatment of epilepsy in children and its influence on the levels of serum leptin and adiponectin(APN).Methods Totally 60 cases of pediatric epilepsy admitted to the Department of Pediatric Neurology in Nanyang Central Hospital from January 2020 to August 2022 were selected.According to different drug groups,20 cases were treated with sodium valproate as the ob-servation group;20 cases were treated with topiramate as control group;20 patients were treated with sodium valproate combined with topiramate as the combination group.The clinical effect,cognitive function score,serum leptin,APN levels and adverse reactions after medication in the three groups were observed.Results After treatment,the total effec-tive rate of the combined group was 95.0％,which was significantly higher than 65.0％in the observation group and 75.0％in the control group(x2=5.219,8.067,P＜0.001).There was no statistical significance in cognitive func-tion scores of the three groups before treatment(P＞0.05),and the total IQ,operational IQ and verbal IQ scores of the combined group were(102.11±3.94),(102.31±2.52)and(99.41±2.63)points.It was significantly higher than that in observation and control group(P＜0.05).There was no significant difference in leptin and APN levels among the three groups before treatment(P＞0.05),and leptin level of the combined group was(5.27±1.16)µg/mL,which was significantly lower than that of the observation and control group;APN level was(15.38±2.24)μg/mL,and it was higher significantly than that of the control and observation group(P＜0.05).Treatment after,the adverse re-actions incidence in group combination was 15.0％,lower significantly than that in observation group(25.0％)and control group(30.0％)(x2=2.351,3.324,P＜0.001).Conclusion Among the three therapeutic methods,sodium valproate combined with topiramate has the most significant therapeutic effect,and the incidence of adverse reactions is lower than that of topiramate,so it can be promoted as the preferred option of clinical treatment.
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