Clinical value of ultrasound combined with serum VEGF and CA125 in diagnosing endometrial pathology in postmenopausal women with asymptomatic endometrial thickening
Objective To explore the clinical value of ultrasound combined with serum vascular endothelial growth factor(VEGF)and carbohydrate antigen 125(CA125)in diagnosing endometrial pathology in postmenopausal women with a-symptomatic endometrial thickening.Methods In this study,80 cases of postmenopausal women with asymptomatic endo-metrial thickening admitted to Zhumadian Central Hospital from April 2022 to April 2023 were included as the case group,and 80 cases of healthy people were selected as the control group.The ultrasonic parameters,serum CA125 and VEGF lev-els of the two groups were compared,and the diagnostic efficacy of the above indicators for endometrial lesions was ana-lyzed through the receiver's working curve(ROC).Results The levels of serum CA125,VEGF,maximum blood flow ve-locity(SP),end diastolic blood flow velocity(ED)and other ultrasonic parameters in the case group were significantly higher than those in the control group,and the resistance index(RI)value was lower(all P＜0.05).ROC curve analysis showed that AUC of ultrasound,serum CA125 and VEGF levels alone and combined detection in diagnosing endometrial pathology were 0.885(95％CI:0.812-0.958),0.785(95％CI:0.681-0.890),0.842(95％CI:0.753-0.931)and 0.949(95％CI:0.905-0.994),respectively.The specificity was 80.09％,82.61％,72.55％and 82.52％.Conclusion The combined use of ultrasound examination and serum CA125 and VEGF levels can significantly improve the diagnostic accuracy of endometrial lesions and provide a more reliable basis for clinical diagnosis and treatment.
Ultrasonic examinationVEGFCA125AsymptomaticEndometrial pathologyDiagnostic value
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