Correlation of serum Hcy and NT-proBNP and hs-CRP levels with cardiac function and prognosis in patients with acute myocardial infarction
Objective To investigate the correlation between serum homocysteine(HCY),N-terminal pro-B-type natriuretic peptide(NT-proBNP)and hypersensitive C-reactive protein(hs-CRP)levels and cardiac function and prognosis in patients with acute myocardial infarction,so as to provide reference for early clinical intervention.Methods A total of 86 patients with acute myocardial infarction in Kaifeng Peoples Hospital from April 2021 to April 2023 were selected,and the serum levels of Hcy,NT-proBNP,hs-CRP and cardiac function indexes[left ventricular end-diastolic diameter(LVDD),left ventricular ejection fraction(LVEF)]of patients with different cardiac function grades were compared.The correlation between serum Hcy,NT-proBNP and hs-CRP levels and cardiac function in pa-tients with acute myocardial infarction was analyzed,the serum Hcy,NT-proBNP and hs-CRP levels in patients with different prognosis were compared,and the relationship between them and the prognosis of patients with acute myocardial infarction was analyzed.Results The levels of serum Hcy,NT-proBNP,hs-CRP and LVDD were compared in patients with different cardiac function grades at admission:Grade Ⅳ＞Grade Ⅲ＞Grade Ⅱ,and LVEF was compared in grade Ⅳ＜Grade Ⅲ＜Grade Ⅱ(P＜0.05).Serum Hcy,NT-proBNP and hs-CRP were positively correlated with cardiac func-tion grade and LVDD,but negatively correlated with LVEF(P＜0.05).Compared with the patients with good prognosis,the serum levels of Hcy,NT-proBNP and hs-CRP were higher in the patients with poor prognosis at admission(P＜0.05).Logistic regression equation analysis showed that serum Hcy,NT-proBNP and hs-CRP were the prognostic factors of patients with acute myocardial infarction(P＜0.05).Conclusion Serum Hcy,NT-proBNP and hs-CRP lev-els are significantly correlated with cardiac function and prognosis in patients with acute myocardial infarction,which pro-vides reference for early clinical assessment of patient prognosis and targeted intervention.
Acute myocardial infarctionHeart functionHomocysteineN-terminal pro-B-type natriuretic peptideHypersensitive C-reactive protein
NETL
NSTL
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