子宫内膜癌MKI67表达与预后的相关性
Correlation between MKI67 expression and prognosis in endometrial cancer
颜舜轩 1黄涛 2黄佳佳 1胡婴丝 1陈昶 2周亚燕 3雷嘉 2卢大林1
作者信息
- 1. 暨南大学医学院流行病学教研室,广州 510000
- 2. 梧州市红十字会医院妇科,广西梧州 543000
- 3. 深圳市人民医院,暨南大学第二临床医学院,南方科技大学第一附属医院肿瘤放疗科,广东深圳 518020
- 折叠
摘要
目的 分析MKI67表达与子宫内膜癌患者临床病理特征及预后的相关性.方法 选择2009年1月至2021年12月于广西梧州市红十字会医院接受手术治疗的322例患者.使用logistic回归分析MKI67表达与临床病理特征的相关性,使用Kaplan-Meier曲线、Log-rank检验和Cox回归分析MKI67表达与预后之间的关系.结果 子宫内膜癌MKI67表达水平与临床病理特征之间存在相关性.MKI67表达和p53水平呈正相关,与雌激素受体(estrogen receptor,ER)和孕激素受体(progesterone receptor,PR)表达水平呈负相关.Cox回归表明MKI67是子宫内膜癌患者术后死亡的危险因素(HR=4.27,95％CI:1.17～15.59);Kaplan-Meier生存曲线显示,相较于MKI67高表达患者,MKI67低表达患者的总生存时间更长,差异有统计学意义(P=0.016).结论 MKI67表达与p53、ER、PR等临床病理特征密切相关.MKI67的表达水平和子宫内膜癌患者的预后相关,MKI67高表达的子宫内膜癌患者的生存率较低.
Abstract
Objective To analyze the correlation between MKI67 expression and clinicopathological features and progno-sis of endometrial cancer patients.Methods Totally 322 patients who underwent surgical treatment from January 2009 to December 2021 in the Red Cross Hospital of Wuzhou City,Guangxi Province,were selected.The correlation between MKI67 expression and clinicopathological characteristics was analyzed using logistic regression,and the association be-tween MKI67 expression and prognosis was analyzed using Kaplan-Meier curves,Log-rank test and Cox regression.Results There was a correlation between MKI67 expression levels and clinicopathological features in endometrial canc-er.MKI67 expression was positively correlated with p53 expression levels and negatively correlated with ER and PR ex-pression levels.Cox regression demonstrated that MKI67 was a risk factor for postoperative death in patients with endom-etrial cancer(HR=4.27,95％CI:1.17-15.59);Kaplan-Meier survival curves showed that patients with low MKI67 expression had longer overall survival time compared to patients with high MKI67 expression,and the difference was statistically significant(P=0.016).Conclusion MKI67 ex-pression is closely associated with clinicopathologic features such as p53,ER,and PR.The expression level of MKI67 is correlated with the prognosis of endometrial cancer pa-tients,and patients with endometrial cancer with high MKI67 expression have a lower survival rate.
关键词
MIK67/子宫内膜癌/总生存/无复发生存Key words
MIK67/Endometrial cancer/Overall survival/Recurrence-free survival引用本文复制引用
基金项目
国家自然科学基金青年项目(82003522)
出版年
2024
NETL
NSTL
万方数据