Clinicopathological characteristics of HER2 low T1-stage breast cancer patients
Objective To analyze the clinicopathological features of HER2 low T1-stage breast cancer patients.Methods Totally 274 patients with T1-stage breast cancer in the general hospital of Puyang Oilfield from January 2011 to December 2020,were divided into three groups according to the expression of HER2:HER2 low goup,HER2 negative group and HER2 positive group.Compared the clinical and pathological characteristics of HER2 in general and in pairs.Results The different expression levels of HER2 were statistically different in age,estrogen receptor(ER)status,Ki-67 expression level,lymph node metastasis and molecular typing(all P＜0.05).Compared with the negative group of HER2,there were statistical differences in the age of onset,ER expression status,lymph node metastasis and molecular typing in the low expression group of HER2(all P＜0.05).Compared with the positive group,the group with low expression of HER2 has more advantages in patients with ER-positive T1 breast cancer with low expression of Ki-67,and the difference is statisti-cally significant(all P＜0.05).However,for lymph node metastasis,multivariate analysis of patients with T1 breast cancer found no independent risk factors.Conclusion From the results of this study,There are some differences in clinicopathologi-cal features among the three groups of T1 breast cancer patients with low expression of HER2,negative expression and positive expression.The N stage is related to the low expression of HER2,while the T stage has nothing to do with it.The low expres-sion of HER2 is the dominant factor of ER-positive T1 breast cancer,which suggests that patients related to these factors should be paid more attention to endocrine therapy in the formulation of treatment plan.
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