Changes of peripheral blood T lymphocyte subsets in patients with systemic lupus erythematosus complicated with pulmonary arterial hypertension and its clinical significance
Objective To analysis and detection of T lymphocyte subsets in systemic lupus erythematosus(SLE sys-temiclupuserythematosus,)merge pulmonary hypertension(pulmonaryarterial hypertension,PAH)of clinical signifi-cance.Methods A retrospective cohort study was conducted to select 178 patients with systemic lupus erythematosus admitted to the First Affiliated Hospital of Zhengzhou University from March 2022 to October 2023,of which 78 pa-tients with active SLE combined with PAH were included in the combined group,50 patients with simple active SLE were included in the uncombined group,and 50 patients with simple inactive SLE were included in the control group.Clinical data including gender,smoking history,drinking history,course of disease,age,body mass index(BMI)and laboratory indexes were retrospectively analyzed.Various laboratory indicators were compared between the uncombined group and the combined group,and T lymphocyte subsets of patients with different disease activity were compared.The correlation between SLE complicated with PAH and periph-eral blood T lymphocyte subsets was analyzed by Perason method,and the influencing factors of SLE complicated with PAH were analyzed by logistic regression method.Results The levels of CD4+and CD4+/CD8+in the combined group were(28.99±7.54)and(0.75±0.24),respectively,lower than those in the non-combined group,and CD8+level was(38.84±6.89)higher than that in the non-combined group(P＜0.05).CD4+/CD8+level(0.97±0.38)was lower than that of control group(1.33±0.56),and CD8+level(33.59±7.41)was higher than that of control group(28.66±4.54)(P＜0.05).Pearson correlation analysis showed that CD4+,CD4+/CD8+were negatively correlated with SLE combined PAH,and CD8+was positively correlated with SLE combined PAH(P＜0.05).Logistic analysis showed that high levels of CD4+and CD4+/CD8+were protective factors for SLE combined with PAH,while high levels of CD8+were risk factors(P＜0.05).Conclusion Compared with patients with active or inactive SLE alone,there is abnormal expression of T lymphocyte subsets in peripheral blood of patients with SLE complicated with PAH.Detection of T lymphocyte subsets can predict the risk of SLE complicated with PAH to guide clinical treatment.
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