女性帕金森病患者认知、运动功能与生育、绝经年龄及血脂的相关性

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中文摘要：目的探讨女性帕金森病(Parkinson's disease，PD)患者认知、运动功能与生育、绝经年龄及血脂水平的关系。方法选取2023年1月至2023年12月新乡市第一人民医院收治的女性PD患者89例，根据蒙特利尔认知评估量表(Montreal Cognitive Assessment，MoCA)评分将 PD 患者分为认知功能障碍(cognitive Impairment，CI)组(MoCA＜26分，38例)与非CI组(MoCA≥26分，51例);根据统一帕金森病评定量表Ⅲ(unified parkinson's dis-ease rating scale-Ⅲ，UPDRS-Ⅲ)评分，将PD患者分为中重度运动障碍组(UPDRS-Ⅲ ≥ 16分，57例)与轻度运动障碍组(UPDRS-Ⅲ＜16分，32例)，比较CI组与非CI组、中重度运动障碍组与轻度运动障碍组临床资料，采用pearson相关分析MoCA评分、UPDRS-Ⅲ评分与生育、绝经年龄及血脂水平的相关性。结果 CI组年龄、首发症状年龄、UPDRS-Ⅲ评分高于非CI组，受教育年限、MoCA评分、绝经年龄、生育年龄、总胆固醇(total cho-lesterol，TC)、甘油三酯(triglyceride，TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol，HDL)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol，LDL)、载脂蛋白 A1(apoprotein A1，Apo A1)低于非 CI 组，差异有统计学意义(P＜0。05);MoCA评分与生育年龄、绝经年龄、TC、TG、HDL、LDL、Apo A1呈正相关(P＜0。05);中重度运动障碍组病程、UPDRS-Ⅲ评分高于轻度运动障碍组，绝经年龄、生育年龄、TC、TG、HDL、LDL、Apo A1低于轻度运动障碍组，差异有统计学意义(P＜0。05);UPDRS-Ⅲ评分与生育年龄、绝经年龄、TC、TG、HDL、LDL、Apo A1呈负相关(P＜0。05)。结论女性PD患者认知、运动功能与生育、绝经年龄及血脂水平存在相关，维持正常激素水平与血脂水平可能对于预防PD有积极作用。

外文标题：Correlation of cognitive and motor function with fertility,menopause age and blood lipid in women with Parkinson's disease

外文摘要：Objective To investigate the relationship between cognitive function,motor function,and fertility,meno-pause age,lipid level in women with Parkinson's disease(PD).Methods Totally 89 female PD patients admitted from Jan to Dec 2023 were selected.According to Montreal Cognitive Assessment(MoCA),PD patients were divided into CI group(38 cases with MoCA＜26 points)and non-CI group(51 cases with MoCA≥26 points).According to Unified Parkinson's Disease Rating Scale-Ⅲ(UPDRS-Ⅲ),PD patients were divided into moderate-severe dyskinesia group(57 cases with UPDRS-Ⅲ ≥16 points)and mild dyskinesia group(32 cases with UPDRS-Ⅲ＜16 points).Clinical data of CI group and non-CI group,moderate-severe dyskinesia group and mild dyskinesia group were com-pared.Pearson correlation analysis was used to analyze the correlation between MoCA score,UPDRS-Ⅲ score and fer-tility,menopause age,lipid level.Results Age,age of first symptom and UPDRS-Ⅲ score in CI group were higher than those in non-CI group,and years of schooling,MoCA score,menopause age,fertility age,total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL),low density lipoprotein cholesterol(LDL),apoprotein A1(Apo A1)were lower than those in non-CI group(P＜0.05).MoCA score was positively correlated with fertility age,menopause age,TC,TG,HDL,LDL,Apo A1(P＜0.05).The duration of disease and UPDRS-Ⅲ score in moderate-severe dyskinesia group were higher than those in mild dyskinesia group,and menopause age,fertility age,TC,TG,HDL,LDL,Apo A1 were lower than those in mild dyskinesia group(P＜0.05).UPDRS-Ⅲ score was nega-tively correlated with fertility age,menopause age,TC,TG,HDL,LDL,Apo A1(P＜0.05).Conclusion The cogni-tive and motor functions of female PD patients are related to fertility,menopause age and lipid levels.Maintaining nor-mal hormone levels and lipid levels may have a positive effect on the prevention of PD.

外文关键词：

FemaleParkinson's diseaseCognitive functionMotor functionChildbearing ageAge of menopauseBlood lipid

作者：

刘丽娇

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作者单位：

新乡市第一人民医院神经内科,河南新乡 453000

关键词：

女性帕金森认知功能运动功能生育年龄绝经年龄血脂

出版年：

2024

DOI：