Analysis of correlation factors between peripheral blood index and bone metastasis in patients with advanced breast cancer
Objective To investigate the correlation between peripheral blood indicators and bone metastasis in patients with advanced breast cancer.Methods A retrospective analysis was conducted on 225 hospitalized female breast cancer patients treated at the First Affiliated Hospital of Xinxiang Medical University from May 2020 to May 2023.The patients were divided into a study group(bone metastasis group,n=55)and a control group(non-bone metastasis group,n=166).Medical records and peripheral blood test results at admission were compared between the two groups.Results The age of breast cancer patients with bone metastasis ranged from 36 to 85 years,with a mean age of(52.65±11.74)years.Among them,22 cases(40.0％)had single-site bone metastasis,and 33 cases(60.0％)had multiple-site bone metastasis,with an overall incidence rate of bone metastasis of 24.4％.There were statistically significant differences in ALP,nutritional metabolism indicators(ALB,HGB),and coagulation indicators(PLT,PT,APTT,TT,Fib,D-D,FDP)between the two groups(P＜0.05);however,there were no statistically significant differences in age and inflammatory indicators(neutrophils,lymphocytes)(P＞0.05).Univariate logistic regression analysis indicated that ALP,nutritional metabolism indicators(ALB,HGB),and coagulation indicators(PLT,PT,APTT,Fib,D-D,FDP)were risk factors for bone metastasis in advanced breast cancer patients(P＜0.05).Multivariate logistic regression analysis showed that ALP was an inde-pendent risk factor for bone metastasis in advanced breast cancer(P＜0.05).Conclusion Breast cancer patients,es-pecially those in advanced stages,should undergo regular monitoring of these indicators to early detect and intervene in the possibility of bone metastasis,thereby improving patient survival rates and quality of life.
Breast cancerBone metastasisALPPeripheral blood indicatorsCoagulation indicators
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