Comparative study of effects of propofol and propofol on postoperative fatigue in patients undergoing thoracoscopic radical resection of lung cancer
Objective To compare the effects of ciprofol and propofol on postoperative fatigue(POF)in patients with thoracoscopic radical mastectomy for lung cancer.Methods One hundred and twenty patients undergoing thoracoscopic radical mastectomy for lung cancer were enrolled and the subjects were allocated into ciprofol group(group C)and propofol group(group P),with 60 subjects in each group,according to a random number table method.Anesthesia in-duction:group C was anesthetized with intravenous injection of 0.4 mg/kg of propofol,group P was anesthetized with intravenous injection of 2.0 mg/kg of propofol,followed by intravenous injection of 0.6-0.8 mg/kg of rocuronium bro-mide and 0.2-0.4 mg/kg of sufentanil in both groups µg/kg.Anesthesia maintenance:group C received intravenous infusion of 0.8～2.4 mg/(kg·h)of propofol;group P received intravenous infusion of propofol 4.0-12.0 mg/(kg·h).Both groups received intravenous infusion of rocuronium 0.1-0.3 μg/(kg·min)and intravenous infusion of remifentanil 0.3-0.6 mg/(kg·h).The main outcomes were the fatigue scale(FSS)scores at 1 day before surgery and 1,3,7 days after surgery were evaluated.The secondary outcomes were as follows:the visual analogue scale(VAS),Ramsay sedation score and the incidence of adverse events were evaluated within 48 hours after surgery.At the same time,peripheral venous blood samples were collected at 1 day before operation,1 day after operation and 3 days af-ter operation to detect the concentrations of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleu-kin-8(IL-8)in serum.Results Compared with 1 d before operation,the FSS scores of the two groups increased at 1,3 and 7 d after surgery(P＜0.05).Compared with the group P,the FSS scores of the group C decreased significantly at 1,3 and 7 days after surgery(P＜0.05).Within 7 days after surgery,23 patients(38.3％)in the group P devel-oped POF,9 patients(15.0％)in the group C developed POF.The incidence of POF in the group C was significantly lower than that in the group P(P＜0.05).The VAS scores and Ramsay sedation scores of the two groups of patients were similar at different time points after surgery within 48 h(P＞0.05).Within 2 days after operation,there was no significant difference in the analgesic remedy rate,total pressing times of PCIA pump and effective pressing times be-tween the two groups(P＞0.05).Compared with group P,the incidence of vomiting in group C was significantly lower within 48 h after operation(P＜0.05).Conclusion Compared with propofol,propofol can significantly reduce the in-cidence of postoperative POF and nausea and vomiting in patients undergoing thoracoscopic radical resection of lung cancer,but has no significant effect on inflammatory response.
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