糖尿病视网膜病变患者的抗血管内皮生长因子方案治疗作用及对炎症因子的影响

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中文摘要：目的分析抗血管内皮生长因子(vascular endothelial growth factor，VEGF)方案对糖尿病视网膜病变患者的治疗效果、炎症因子、视力状态等情况的影响结果。方法选取就诊于周口市中心医院82例糖尿病视网膜病变患者，时间为2022年4月-2023年6月，按照治疗方法进行分组，以视网膜激光光凝治疗为对照组，实施抗VEGF方案治疗为观察组，于治疗前、治疗后6个月比较两组视网膜神经纤维层厚度、最佳矫正视力、眼压水平、炎症因子[C反应蛋白(C-reactive protein，CRP)、白介素-2(interleukin-2，IL-2)、白介素-6(interleukin-6，IL-6)、肿瘤坏死因子-a(tumor necrosis factor-α，TNF-α)及可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1，sICAM-1)]、疗效及并发症。结果观察组各方向的视网膜神经纤维层厚度扫描时间短于对照组差异有统计学意义(P＜0。05);观察组最佳矫正视力(0。55±0。13)高于对照组(0。42±0。12)，眼压水平为(14。32±1。21)mmHg低于对照组的(16。52±1。22)mmHg;观察组 CRP 为(9。52±3。42)mg/L、IL-2 为(71。52±11。35)ng/L、IL-6 为(21。34±6。44)ng/L、TNF-α 为(23。15±11。52)ng/L、sICAM-1 为(362。45±77。44)μg/L 低于对照组的(15。62±3。33)mg/L、(82。35±11。33)ng/L、(33。52±6。42)ng/L、(36。85±11。32)ng/L、(453。45±76。25)μg/L 差异有统计学意义(P＜0。05);疗效比较(95。12％vs 75。61％)，观察组更高;并发症比较(4。88％vs 26。83％)，观察组更低，差异有统计学意义(P＜0。05)。结论经抗VEGF方案治疗可有效减轻患者炎症反应，促使视网膜神经纤维层厚度变薄，降低眼压，提高患者视力水平，其效果显著，且并发症较少，值得推广。

外文标题：Effects of anti vascular endothelial growth factor regimen on inflammatory factors in patients with diabetes retinopathy

外文摘要：Objective To analyze the effect of anti vascular endothelial growth factor(VEGF)regimen on the treatment effect,inflammatory factors,visual acuity and other conditions of patients with diabetes retinopathy.Methods Totally 82 patients with diabetes retinopathy were selected in the Zhoukou Central Hospital from April 2022 to June 2023.They were divided into two groups according to the treatment method.The control group was treated with retinal laser photo-coagulation,and the observation group was treated with anti VEGF regimen.The thickness of retinal nerve fiber layer,best corrected visual acuity,intraocular pressure,inflammatory factors C-reactive protein(CRP),interleukin(IL)were compared between the two groups before treatment and six months after treatment-2.IL-6,tumor necrosis factor-α(TNF-α),soluble intercellular adhesion molecule-1(sICAM-1),efficacy and complications.Results The scanning time of retinal nerve fiber layer thickness in all directions in the observation group was shorter than that in the control group(P＜0.05);the best corrected visual acuity of the observation group(0.55±0.13)was higher than that of the control group(0.42±0.12),and the intraocular pressure level was(14.32±1.21)mmHg lower than that of the control group(16.52±1.22)mmHg;the CRP of the observation group was(9.52±3.42)mg/L,IL-2 was(71.52±11.35)ng/L,IL-6 was(21.34±6.44)ng/L,TNF-α was(23.15±11.52)ng/L,and sICAM-1 was(362.45±77.44)µg/L was lower than the control group's(15.62±3.33)mg/L,(82.35±11.33)ng/L,(33.52±6.42)ng/L,(36.85±11.32)ng/L,(453.45±76.25)µg/L(P＜0.05);comparison of thera-peutic effects(95.12％vs 75.61％),the observation group showed higher efficacy;the comparison of complications(4.88％vs 26.83％)was lower in the observation group,with a significant difference(P＜0.05).Conclusion The anti VEGF regimen can effectively alleviate inflammation in patients,promote thinning of the retinal nerve fiber layer,reduce intraocular pressure,and improve visual acuity.The effect is significant and there are fewer complications,which is worth promoting.

外文关键词：

Diabetes retinopathyTreatment with anti vascular endothelial growth factor regimenInflammatory factorsTherapeutic effectComplications

作者：

张翼

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作者单位：

周口市中心医院内分泌科,河南周口 466000

关键词：

糖尿病视网膜病变抗血管内皮生长因子方案治疗炎症因子疗效并发症

出版年：

2024

DOI：