Effect of strontium chloride combined with zoledronic acid in treatment of non-small cell lung cancer patients with bone metastasis
Objective To observate of the therapeutic effect of strontium chloride(89Sr)combined with zoledronic acid on non-small cell lung cancer(NSCLC)patients with bone metastases,providing a basis for the medication regimen of such patients.Methods Totally 116 NSCLC patients with bone metastases treated in the Nanyang Central Hospital from May 2021 to May 2023 were randomly divided into 89Sr group and combined group,with 58 patients in each group.89Sr group was treated with 89Sr alone,and the combined group was treated with 89Sr combined with zoledronic acid.The ef-fective rate,pain degree,hematological toxicities and side effects,quality of life before and after treatment were com-pared between the two groups.Results The total effective rate of combination group(60.34％)was higher than that of 89Sr group(20.69％)(P＜0.05).After treatment,the percentages of pain grade 0(15.52％)and I(48.28％)in combination group were higher than those in 89Sr group(0.00％,20.69％),and the percentages of pain grade Ⅱ(31.03％)and Ⅲ(5.17％)in combination group were lower than those in 89Sr group(51.72％,27.59％)(P＜0.05).After treatment,the WBC and platelet values in combination group were(3.63±0.91)× 109/L and(121.37±24.82)× 109/L,respectively,which were lower than those in 89Sr group(4.12±0.83)× 109/L and(136.83±18.74)×109/L(P＜0.05).The incidence of adverse reactions in combination group was 12.07％,which was not significantly different from 20.69％in control group(P＞0.05).After treatment,the scores of physical function,role function,cognitive function,emotional function and social function in the combined group were(71.58±8.82)scores,(68.76±6.78)scores,(64.02±5.22)scores,(61.74±6.04)scoresand(58.76±6.96)scores,respectively.They were higher than those in 89 Sr group(57.73±5.98),(58.78±6.35),(53.45±5.81),(56.72±5.26)and(52.27±5.63)(P＜0.05).Conclusion 89 Sr combined with zoledronic acid can improve the treatment efficiency of NSCLC bone metastases,significantly improve pain symptoms,reduce the side effects of treatment,and improve the quality of life of patients.
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