目的 探讨不同玻璃化冷冻时间对冻融胚胎移植(frozen-thawed embryo transfer，FET)单/双胎妊娠结局及新生儿出生结局的影响。方法 选择2010年1月-2020年12月在焦作市妇幼保健院生殖医学中心行FET助孕的患者，根据患者胚胎玻璃化冷冻保存时间将患者分为四组:(≥2～3)年为A组，(≥3～5)年为B组，(≥5～7)年为C组，≥7年以上为D组，而后按分娩新生儿的数目将患者分为单胎分娩组和双胎分娩组，首先分别比较组间患者年龄、体质量数(body mass index，BMI)=体重/身高2(kg/m2)、基础 FSH(basal follicle stimulating hormone，bFSH)、基础黄体生成素(luteinizing hormone LH)、基础雌二醇(estradion E2)、解冻移植方案、移植胚胎数目、移植胚胎类别、移植日子宫内膜厚度、患者分娩的孕周、新生儿出生体重、早产率、剖宫产率、小于胎龄儿(small for gestation age infant，SGA)、巨大儿率、出生缺陷率、新生儿死亡率及妊娠并发症(包括妊娠期糖尿病、妊娠期高血压疾病、产后出血、胎盘早剥、前置胎盘)进行比较。结果 总体:随着冷冻时间的延长，胚胎复苏率有下降趋势，但组间比较差异无统计学意义(P＞0。05);单胎分娩组:胚胎冷冻时间≥7年以上组的SGA率高于其他组，且差异有统计学意义(P＜0。05);双胎分娩组:组间妊娠结局及出生子代结局无差异。结论 ①胚胎冷冻保存≥7年，将增加单胎分娩子代SGA率;②胚胎长期玻璃化冷冻保存对双胎妊娠结局及出生子代无显著影响。
Pregnancy outcome and neonatal outcome analyzed of embryo cryopreservation time underwent frozen-thawed embryo transfer
Objective To investigate the pregnancy outcome and neonatal outcome of embryo cryopreservation time underwent frozen-thawed embryo transfer.Methods The clinical data of the frozen embryo transfer cycles in the Reproductive Medi-cine Center of the Jiao zuo Maternal and Child Health Hospital were retrospectively analyzed from January 2010 to December 2020.According to cryopreservation time of embryos,the embryos were divided into 4 groups,(≥2-3)years(Group A),(≥3-5)years(Group B),(≥5-7)years(Group C),≥7years(Group D),and according to the number of newborns delivered,the patients were divided into singleton group and twin group.Compared the patient age,Infertility causes,body mass index,basic of follicle-stimulation homone,insemination technology,Number of embryos transferred,proportion of No of embryos transferred,proportion of type of embryos transferred,Embryo quality at transfer,Endometrium preparation,estradion and endo-metriai thickness on the day of embryo transfer,Embryonic survival rate,the Gestational age of delivery,birth weight,preterm birth rate,cesarean section rate,Small for gestation age infant,Morbidity of pregnancy complications(including,Gestational diabetes,Gestational hypertension,Pastpartum hemorrhage,Placenta previa,Placenta increta rate).Results ①With the pro-long of cryopreservation time,the overall embryonic survival rate was decreased,but the difference was not statistically signifi-cant(P＞0.05);② embryo cryopreservation time increased the risk of SGA in singleton pregnancy,and the difference was statistically significant(P＜0.05);③ embryo cryopreservation time did not increase the risk of twin pregnancy outcome and neonatal outcome,and the difference was not statistically signifi-cant(P＞0.05).Conclusion ① Embryo cryopreservation time increase the risk of SGA in singleton pregnancy;② embryo cryopreservation time dose not increase the risk of twin pregnancy outcome and neonatal outcome.
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