Application of microwave hyperthermia assisted chemoradiotherapy in brain glioma
Objective To investigate the effects of microwave hyperthermia assisted chemoradiotherapy on short-term efficacy,improvement of symptoms associated with chemoradiotherapy,treatment compliance and satisfaction in patients with glioma.Methods A total of 80 patients with brain glioma were selected from the Department of Radiotherapy,the First Affiliated Hospital of Zhengzhou University from June 2022 to March 2024,with 46 cases in the observation group and 34 cases in the control group.The control group was treated with radiotherapy and chemotherapy according to NCCN guidelines.Volumetric arc-shaped intensity modulated radiotherapy(VMAT)was used for radiotherapy,with a total dose of 50～60G yand 1.8～2.00 Gy/time.Chemotherapy was administered with temozolomide 75mg/m2 orally once a day.The observation group received microwave hyperthermia on the basis of chemoradiotherapy.Before and 8 weeks af-ter treatment,SAS and SDS scales were used to evaluate the anxiety and depression status of patients in both groups,and PSQI questionnaire was used to evaluate the sleep status of patients in both groups.The differences of treatment compliance and satisfaction between the two groups were evaluated by self-made questionnaire.The differences of cre-atinine,mannitol,glycerol fructose,hormones,diuretics and peripheral venous vessel damage were compared between the two groups during treatment.Results The observation group was superior to the control group in anxiety,depression and sleep,and the difference was statistically significant(P＜0.05).Treatment satisfaction(86.96％vs 58.88％)and treatment compliance(80.43％vs 61.76％)in the observation group were higher than those in the control group,and peripheral venous vessel damage was better than that in the control group(26.09％vs 94.12％,P＜0.05).During treatment,the creatinine value of observation group was lower than that of control group,and the days of glycerin fruc-tose use were less than that of control group,but the difference was not statistically significant(P＞0.05).The use days of mannitol,hormone and diuretic were less than those in the control group,(P＜0.05).Conclusion Microwave hyperthermia can relieve anxiety and depression in patients with glioma,improve their sleep status,reduce the utilization rate of mannitol,diuretic and hormones,protect renal function and peripheral blood vessels,and improve treatment com-pliance and treatment satisfaction,which is worthy of clinical promotion.
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