Significance of advanced lung cancer inflammatory index in immunophenotype and prognosis of patients with multiple myeloma
Objective To explore the correlation between advanced lung cancer inflammatory index(ALI)and immunophe-notype of patients with multiple myeloma(MM)and its clinical significance in patient prognosis.Methods Totally 126 MM patients treated in the First Affiliated Hospital of Xinxiang Medical University from August 2020 to August 2023 were retro-spectively analyzed.Their immunophenotypes of CD56,CD117 and CD200 were analyzed,and their ALI were calculated ac-cording to the clinical data and related biochemical test results.Patients were divided into remission group and non-remission group according to chemotherapy results.ALI differences between the two groups were compared and receiver operating char-acteristic(ROC)curve analysis was performed to obtain the cut-off value of ALI.The patients were divided into the high ALI group(n=56)and low ALI group(n=70),and differences in clinical characteristics,immunophenotype and survival be-tween different groups were compared.Cox regression analysis was performed to determine whether ALI was an influential fac-tor in progression-free survival(PFS)and overall survival(OS)of MM patients.Results ALI in the remission group was significantly higher than that in non-remission group(t=3.766,P＜0.001);the optimal ALI cut-off value was 36.5.The proportion of patients with extramedullary involvement,Ⅲ ISS stage,β2-microglobulin,LDH and abnormal plasma cell ratio in low ALI group were significantly higher than those in high ALI group(all P＜0.05);the proportion of CD56 positive in the low ALI group was significantly lower than that in the high ALI group(P＜0.05),no significant difference was found between other immunophenotypic groups(P＞0.05);both the PFS and OS of the low ALI group were significantly lower than those of the high ALI group(x2=9.668,P＜0.001;x2=12 689,P＜0.001),and higher ALI was an independent protective factor for PFS and OS(P＜0.05).Conclusion ALI in MM patients is closely related to clinical features such as extramedullary involvement and CD56 immunophenotype,and high ALI is an independent protective factor for the prognosis and survival of patients.
Multiple myelomaAdvanced lung cancer inflammation indexNeutrophil to lymphocyte ratioImmunophe-notypePrognosis
NETL
NSTL
万方数据
