中药内异消联合GnRH-a对卵巢子宫内膜异位囊肿保守性术后保护卵巢功能的临床观察

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中文摘要：目的观察中药内异消联合促性腺激素释放激素激动剂(gonadotropin-releasing hormone agonist，GnRH-a)对卵巢子宫内膜异位囊肿保守性术后保护卵巢功能的临床疗效。方法选取80例在浦南医院及上海中医药大学附属曙光医院接受子宫内膜异位囊肿保守性手术治疗的患者，分对照组与研究组各40例，对照组采用GnRH-a(注射用醋酸曲普瑞林)治疗，研究组在对照组的基础上加用中药内异消方剂治疗，测定两组治疗前、治疗结束后3个月血清抗米勒管激素(anti-müllerian hormone，AMH)、肿瘤标志物CA125、卵泡刺激素(folli-cle-stimulating hormone，FSH)、黄体生成素(luteinizing hormone，LH)水平，比较两组中医症候积分。结果经过统计学分析，本研究中的治疗组相较于对照组展现出更高的总有效率(P＜0。05)。在治疗前，两组受试者在各项参数上的比较并未显示出显著差异(P＞0。05)。然而，治疗后，研究组在中医症候积分方面的降低幅度显著大于对照组(P＜0。05)，症状改善程度相较于对照组有更为明显的提升。AMH、CA125高于对照组(P＜0。05)，FSH、LH低于对照组，差异具有统计学意义(P＜0。05)。结论在卵巢子宫内膜异位囊肿保守性术后采用中药内异消方剂联合GnRH-a治疗可改善患者卵巢功能。

外文标题：Clinical effect of traditional Chinese medicine Neiyi Xiao combined with GnRH-a on protecting ovarian function after conservative surgery for ovarian endometrial cyst

外文摘要：Objective To evaluate the therapeutic efficacy of the combination treatment with traditional Chinese medicine Neiyi Xiao and gonadotropin-releasing hormone agonists(GnRH-a)on the preservation of ovarian function following conservative surgical intervention for ovarian endometrial cysts.Methods Totally 80 patients who underwent conserva-tive surgery for ovarian endometrial cyst in Punan Hospital and Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine were selected and divided into a control group and a study group with 40 cases each.The con-trol group was treated with GNRH-a(triptorelin acetate for injection),and the study group was treated with traditional Chinese medicine Neiyi Xiao prescription based on the control group.Serum anti-müllerian hormone(AMH),tumor marker CA125,follicle-stimulating hormone(FSH),and luteinizing hormone(LH)levels were measured before and three months after treatment in both groups.The traditional Chinese medicine(TCM)syndrome scores of the two groups were compared.Results After statistical analysis,the study group showed a higher total effective rate than the control group(P＜0.05).Before treatment,there was no significant difference in the parameters between the two groups of subjects(P＞0.05).After treatment,the reduction in TCM syndrome scores in the study group was significantly greater than that in the control group(P＜0.05),and symptoms improvement was more pronounced compared to the control group.AMH and CA125 were higher than those of the control group(P＜0.05),while FSH and LH were lower than those of the control group,and the difference was statistically singinficant(P＜0.05).Conclusion The use of tradi-tional Chinese medicine Neiyi Xiao prescription combined with GnRH-a therapy can improve ovarian function in pa-tients with ovarian endometrioma after conservative surgery.

外文关键词：

Traditional Chinese medicineNeiyi Xiao prescriptionOvarian functionGonadotropin-releasing hormone agonistOvarian endometrial cyst

作者：

张保华、徐红、蒋春露、胡明珠、聂启勤、周小莉、张俊伟、李庆

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作者单位：

上海交通大学附属仁济医院浦南分院妇产科,上海 200125

上海市闵行区浦江社区卫生服务中心全科,上海 201112

上海市浦东新区上钢社区卫生服务中心全科,上海 200126

关键词：

中药内异消方剂卵巢功能促性腺激素释放激素激动剂卵巢子宫内膜异位囊肿

基金：

上海市综合医院中西结合项目上海市浦东新区中西医协同旗舰科室项目

项目编号：

ZHYY-ZXYJHZX-202108YC-2023-0407

出版年：

2024

DOI：

10.20159/j.cnki.jmf.2024.18.019

医药论坛杂志

中华预防医学会，河南省医学情报研究所

医药论坛杂志

影响因子：0.47

ISSN：1672-3422

年,卷(期)：2024.45(18)