Investigation on influencing factors of pancreatitis after laparoscopic cholecystectomy
Objective To investigate the influencing factors of pancreatitis after laparoscopic cholecystectomy(LC).Methods The general data of 112 patients who underwent LC in the First Affiliated Hospital of Zhengzhou University from July 2020 to August 2022 were retrospectively analyzed.One month after surgery,according to Chinese Guidelines for Diagnosis and Treatment of Acute Pancreatitis(Shenyang,2019),the patients were divided into a pancreatitis group(n=11)and a non-pancreatitis group(n=101)according to whether they developed pancreatitis.Basic data(gen-der,age,course of disease,BMI,history of alcohol consumption,history of pancreatic disease,combined hyperlipi-demia,gallbladder wall thickness,gallbladder size,number,diameter and characteristics of stones,etc.)were collect-ed.Multivariate analysis was performed in univariate and logistic regression models to identify independent factors affect-ing postoperative delayed healing in children with long shaft fractures of the limbs,and ROC curve was drawn to analyze diagnostic efficacy.Results There were no significant differences between the two groups in gender,course of disease,BMI index,history of alcohol consumption,hyperlipidemia,gallbladder wall thickness,gallbladder size,number of stones,diameter,operation time and angiography times(P＞0.05),but there were significant differences between the two groups in age,history of pancreatic disease,stone characteristics and pancreatic duct imaging(P＜0.05).Logistic re-gression model multivariate analysis,age(P=0.023,OR=1.146),history of pancreatic disease(P=0.013,OR=6.424),lithiasis characteristics(P＜0.001,OR=1.644),pancreatic duct development(P＜0.001,OR=2.606)were independent factors of postoperative pancreatitis.According to ROC curve analysis,the AUC value of the estab-lished risk assessment model(age,history of pancreatic disease,lithiasis characteristics,pancreatic duct imaging com-bined detection)was the highest,which was 0.991,and the sensitivity and specificity were 90.90％and 81.81％,re-spectively.Conclusion Age,history of pancreatic disease,characteristics of calculi and pancreatic duct imaging are independent influencing factors for postoperative pancreatitis after LC.Relevant factors should be effectively controlled in clinic and targeted prevention and treatment measures should be taken to reduce the risk of postoperative pancreatitis.
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