血清25-羟维生素D3和T淋巴细胞亚群与儿童哮喘发病风险的相关性研究
Correlation between serum 25-hydroxyvitamin D3 and T lymphocyte subsets and the risk of developing asthma in children
冯日昇 1侯杰 1张松林 1郭燕军1
作者信息
- 1. 郑州大学附属儿童医院东三街院区呼吸二病区,郑州 450000
- 折叠
摘要
目的 研究血清25-羟维生素D3和T淋巴细胞亚群与儿童哮喘发病风险的相关性.方法 收集2021年7月-2023年10月郑州大学附属儿童医院收治的100例患有儿童哮喘的患者作为试验组,另选取100例经体检健康的儿童作为对照组,提取两组试验对象的血清样本,检测血清25-羟维生素D3与T淋巴细胞亚群水平.结果 试验组儿童血清25-羟维生素D3水平[(40.41±4.89)ng/mL]相比于对照组儿童[(55.59±7.96)ng/mL]明显降低,差异有统计学意义(P＜0.05).试验组儿童血清样本T淋巴细胞亚群中CD3+、CD4+、CD4+/CD8+水平低于对照组,差异具有统计学意义(P＜0.05).两组CD8+水平差异无统计学意义(P＞0.05).回归分析结果显示,血清25-羟维生素D3与T淋巴细胞亚群中CD3+、CD4+、CD4+/CD8+与儿童哮喘发生具有相关性(P＜0.05),为独立风险因素;T淋巴细胞亚群中CD8+与儿童哮喘的发生无相关性(P＞0.05).结论 血清25-羟维生素D3水平降低、T淋巴细胞亚群中CD3+、CD4+、CD4+/CD8+不足,与儿童哮喘的发生具有相关性,是儿童哮喘发病的独立危险因素.在临床中需加强儿童哮喘患者血清25-羟维生素D3水平的检测并及时补充维生素D制剂.
Abstract
Objective To investigate the association of serum 25-hydroxyvitamin D3 and T lymphocyte subsets with the risk of asthma in children.Methods Totally 100 patients with childhood asthma admitted to Zhengzhou University Af-filiated Children's Hosipital from July 2021 to October 2023 were selected as the test group,and another 100 healthy children were selected as the control group.Serum samples of the two groups were extracted to detect the levels of serum 25-hydroxyvitamin D3 and T lymphocyte subsets.Results The serum 25-hydroxyvitamin D3 level of experimental group[(40.41±4.89)ng/mL]was significantly lower than that of control group[(55.59±7.96)ng/mL](P＜0.05).The content of CD3+,CD4+,and CD4+/CD8+ in T lymphocyte subpopulations in serum samples of chil-dren in the test group were extremely relatively low than that in those in the content of the people in the healthy group,and the difference between the two groups was statistically significant(P＜0.05);there was no statistically significant a-bout the difference of CD8+content between the two groups(P＞0.05).Regression analysis results showed that serum 25-hydroxyvitamin D3 and CD3+,CD4+,CD4+/CD8+ in T lymphocyte subgroups were related to the occurrence of childhood asthma(P＜0.05),and were independent risk factors;in T lymphocyte subgroups,CD8+ has no correlation with the occurrence of childhood asthma(P＞0.05).Conclusion Reduced serum 25-hydroxyvitamin D3 levels and insufficient CD3+,CD4+,and CD4+/CD8+ in T lym-phocyte subpopulations are related to the occurrence of childhood asthma and are independent risk factors for the onset of childhood asthma.In clinical practice,it is necessary to strengthen the detection of serum 25-hydroxyvitamin D3 levels in children with asthma and to promptly supplement vitamin D preparations.
关键词
血清25-羟维生素D3/T淋巴细胞亚群/儿童哮喘Key words
Serum 25-hydroxyvitamin D3/T lymphocyte subsets/Childhood asthma引用本文复制引用
基金项目
河南省医学科技攻关计划联合共建项目(2018020652)
出版年
2024
NETL
NSTL
万方数据