Correlation between serum 25-hydroxyvitamin D3 and T lymphocyte subsets and the risk of developing asthma in children
Objective To investigate the association of serum 25-hydroxyvitamin D3 and T lymphocyte subsets with the risk of asthma in children.Methods Totally 100 patients with childhood asthma admitted to Zhengzhou University Af-filiated Children's Hosipital from July 2021 to October 2023 were selected as the test group,and another 100 healthy children were selected as the control group.Serum samples of the two groups were extracted to detect the levels of serum 25-hydroxyvitamin D3 and T lymphocyte subsets.Results The serum 25-hydroxyvitamin D3 level of experimental group[(40.41±4.89)ng/mL]was significantly lower than that of control group[(55.59±7.96)ng/mL](P＜0.05).The content of CD3+,CD4+,and CD4+/CD8+ in T lymphocyte subpopulations in serum samples of chil-dren in the test group were extremely relatively low than that in those in the content of the people in the healthy group,and the difference between the two groups was statistically significant(P＜0.05);there was no statistically significant a-bout the difference of CD8+content between the two groups(P＞0.05).Regression analysis results showed that serum 25-hydroxyvitamin D3 and CD3+,CD4+,CD4+/CD8+ in T lymphocyte subgroups were related to the occurrence of childhood asthma(P＜0.05),and were independent risk factors;in T lymphocyte subgroups,CD8+ has no correlation with the occurrence of childhood asthma(P＞0.05).Conclusion Reduced serum 25-hydroxyvitamin D3 levels and insufficient CD3+,CD4+,and CD4+/CD8+ in T lym-phocyte subpopulations are related to the occurrence of childhood asthma and are independent risk factors for the onset of childhood asthma.In clinical practice,it is necessary to strengthen the detection of serum 25-hydroxyvitamin D3 levels in children with asthma and to promptly supplement vitamin D preparations.
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