Effects of dexmedetomidine on Oxidative stress and cognitive postoperative function in elderly patients with prostate cancer undergoing laparoscopic radical surgery
Objective To investigate the effects of dexmedetomidine pump injection on cognitive function and oxidative stress in elderly patients with prostate cancer after laparoscopic radical resection under anesthesia induction intubation.Methods Totally 86 cases of elderly patients aged 60-80 years old undergoing laparoscopic radical surgery in the First Affiliated Hospital of Zhengzhou from Septmber 2022 to August 2023 were selected as the study subjects,and divided into group control and group observation with 43 cases in each based on the method of randomized numerical table.Dexmedeto-midine anesthesia was used to perform the surgery for the observation patients.Before the induction of anesthesia,1d post-operatively and 3 d postoperatively were taken as the observation nodes,which were recorded as To,T,and T2,respective-ly,and the patients'cognitive status was assessed by using the MoCA score,and their serological indexes were measured.Taking preoperative,2 h at the beginning of surgery,and 24 h postoperatively as observation nodes,noted as M0,M1,M2,the serum malondialdehyde and reactive oxygen cluster levels of the two groups of patients were measured and com-pared,and the patients'oxidative stress response was observed.Results At the level of cognitive function,the difference in cognitive levels of the two groups of patients in To and T2 based on MoCA assessment was not statistically significant(P＞0.05);the group observation for T1 score[(26.15±1.53)points]was significantly higher than that of control group[(22.97±1.42)points],and the difference between groups was statistically significant(P＜0.05).At the level of serological indexes,SOD levels at T,and T2 nodes in the observation group were[(325.74±24.52)μ/mL,(285.45±25.98)μ/mL]and NSE levels were[(17.38±3.49)µg/1,(22.77±3.51)μg/l],respectively,which were lower than group control(P＜0.05).There was no significant difference in MDA and ROS levels at Mo nodes between the two groups(P＞0.05).The levels of MDA and ROS at M,and M2 nodes in the observation group were(11.09±2.33)μmol/mL,(9.61±3.03)μmol/mL,(118.36±18.37)μmol/mL,(115.64±21.46)μmol/mL.The difference was statistically signifi-cant(P＜0.05).Conclusion Dexmedetomidine helps to improve postoperative cognitive function,alleviate oxidative stress and improve prognosis,which has high clinical application value.
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