Analysis of carotid plaque characteristics and expression of serum miR-133 b in patients with atherosclerotic acute cerebral infarction
Objective To investigate the characteristics and properties of carotid plaque in patients with atherosclerotic acute cerebral infarction,in order to provide reference for early prevention,and to observe the value of serum miR-133b expression in the diagnosis of cerebral infarction.Methods A total of 300 patients with atherosclerotic acute cere-bral infarction admitted to Zhoukou Central Hospital from January 2022 to December 2023 were selected as the observa-tion group,and 100 patients with simple carotid atherosclerosis were selected as the control group.Carotid plaque ultra-sound,miR-296-5p and miR-133b levels of patients with different degree of neurological impairment and athero-sclerotic acute cerebral infarction in two groups were retrospectively analyzed.Results There were 1 623 carotid plaque detected in the observation group,the average plaque thickness was(1.88±0.27)mm,and 565 carotid plaque detected in the control group,the average plaque thickness was(1.84±0.29)mm.There was no statistical significance between the two groups(P＞0.05).The expression level of miR-133 b in the observation group was 0.05(0.02,0.20),which was significantly higher than that in the control group 0.56(0.37,1.03)(P＜0.05).The expression level of miR-296-5p in the observation group was 0.96(0.42,2.39),which had no statistical significance compared with that in the control group 0.33(0.11,4.07)(P＞0.05).552 carotid plaques were detected in the moderate and severe neurological impairment group,with an average plaque thickness of(1.85±0.24)mm,and 1 058 carotid plaques were detected in the moderate neurological impairment group,with an average plaque thickness of(1.90±0.30)mm,with no statistically significant difference between the two groups(P＞0.05).The rate of mixed echo and irregular shape in moderate and severe neurological impairment group was higher than that in moderate neurological impairment group(P＜0.05).The two groups of data were placed in the state variable column of the ROC classification in SPSS software,and the two factors miR-296-5p and miR-133b were used as test variables to draw the area AUC under the ROC curve and the corresponding 95％confidence interval,and the best truncation value was selected corresponding to the maximum value.AUC indicates the accuracy of disease prediction,and the higher the value,the higher the accuracy.The AUC value of miR-133b is 0.871,higher than that of miR-296-5p,0.437,indicating that miR-133b has higher predictive value.Conclusion The characteristics of carotid plaque in patients with atherosclerotic acute cerebral infarction are mainly irregular shape and mixed echo,and the nature of vulnerable plaque is generally fragile plaque.Rupture of vulnerable carotid plaque is an important risk factor for the occurrence of acute cerebral infarction.miR-133 b was negatively correlated with the severity of the disease and may be used as a potential biomarker for the diagnosis of ACI.
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