Comparison of the application of indobufen or aspirin combined with clopidogrel and tirofiban in patients with acute myocardial infarction after PCI
Objective To compare the application effects of indobufen or aspirin combined with clopidogrel and tirofiban in patients with acute myocardial infarction(AMI)after PCI.Methods A retrospective analysis was conducted on the data of 90 AMI patients treated with PCI at Pingmei Shenma Medical General Hospital from October 2021 to September 2023.According to different post PCI treatment plans,they were divided into a control group(n=49)and an observation group(n=41).The control group was treated with aspirin combined with clopidogrel and tirofiban,while the observation group was treated with in-dobufen combined with clopidogrel and tirofiban.The platelet function(platelet adhesion rate,platelet aggregation rate),ser-um inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],and cardiac function[left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD)]were compared between two groups,and record the incidence of adverse reactions[gastrointestinal reactions(nausea,vomiting,abdominal pain,bloating),allergic reactions,bleeding]in patients.Results After treatment,the platelet adhesion and aggregation rates in both groups decreased,and the difference was statistically significant(P＜0.05),while there was no significant difference between the groups(P＞0.05).After treatment,CRP,TNF-α,and IL-6 in both groups significantly decreased slightly,and the difference was statistically significant(P＜0.05),while there was no significant difference between the groups(P＞0.05).After treatment,LVEF increased and LVEDD decreased in both groups,and the difference was statisti-cally significant(P＜0.05),while there was no significant difference between the groups(P＞0.05).The incidence of gas-trointestinal reactions in the observation group(12.20％)was lower than that in the control group(30.61％),and the differ-ence was statistically significant(x2=4.381,P=0.036).Conclusion Indobufen or aspirin combined with clopidogrel and tirofiban have similar therapeutic effects in AMI patients after PCI,both of which can inhibit platelet activity,alleviate inflam-mation,and improve heart function.Meanwhile indobufen is safer.
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