Effect of remimazolam anesthesia on postoperative delirium in elderly patients with hip fractures undergoing general anesthesia surgery
Objective To analyze the effect of remimazolam and propofol anesthesia on postoperative delirium in elderly patients with hip fractures undergoing general anesthesia surgery.Methods Totally 80 elderly patients who underwent general anesthesia surgery for hip fractures in the Second People's Hospital of Xinxiang from August 2021 to August 2023 were selected and numbered according to the admission sequence,and were randomly divided into remimazolam group(group R,n=40)and propofol group(group P,n=40)by using the random number table method.Group R was given 0.2-0.4mg/kg of remimazolam for anesthesia induction and 0.3-0.5 mg/(kg·h)of remimazolam for anesthesia ma-intenance,and group P was given 1.5-2mg/kg of propofol for anesthesia induction and 4-8 mg/(kg·h)of propofol for anesthesia maintenance.The perioperative status,occurrence of postoperative delirium,postoperative MMSE score,serum inflammatory factors levels and occurrence of perioperative adverse reactions were compared between both groups.Results The dosage of vasoactive drug in group R was significantly less than that in group P(P＜0.05),but there were no statistically significant differences in the incidence rate,type and duration of postoperative delirium between the two groups(P＞0.05).There was no statistical significance in MMSE score between the two groups at 1 day and 3 days after surgery(P＞0.05).The levels of serum IL-6 and CRP in group R at 24 hours after surgery were significantly low-er than those in group P(P＜0.05).The incidence rates of perioperative hypotension and injection pain were signifi-cantly lower in group R than those in group P(P＜0.05),but there was no significant difference in the incidence rates of perioperative nausea,vomiting,respiratory depression and agitation between the two groups(P＞0.05).Conclusion Compared with propofol,remimazolam does not increase the risk of postoperative delirium in elderly pa-tients undergoing general anesthesia surgery for hip fractures.
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