Relationship between lymphocyte surface antigens and TSP-1 level and myocardial injury in patients with sepsis
Objective To analyze and study the relationship between lymphocyte surface antigens,thrombospondin-1(TSP-1)level and myocardial injury in patients with sepsis.Methods A total of 180 patients with sepsis admitted to the Zhengzhou Peoples Hospital from January 2022 to January 2024 were selected and divided into myocardial injury group(n=85)and non-myocardial injury group(n=95)according to the presence or absence of myocardial injury.The im-mune function(CD4+,CD8+,CD4+/CD8+),serum TSP-1 level,myocardial injury indicators[creatine kinase isoenzyme MB(CK-MB),heart-type fatty acid binding protein(H-FABP),N-terminal pro-brain natriuretic pep-tide(NT-proBNP)and cardiac troponin Ⅰ(cTnⅠ)]and echocardiographic indicators[left ventricular ejection fraction(LVEF),mitral valve diastolic flow velocity ratio(E/A)and cardiac output(CO)]were compared between both groups,and the correlation between immune function,TSP-1 level and myocardial injury indicators and echocardiographic indica-tors in patients with sepsis complicated with myocardial injury was analyzed.Receiver operating characteristic(ROC)curve and area under the curve(AUC)were used to analyze the predictive value of serum TSP-1 on sepsis with myocar-dial injury.Results The peripheral blood CD8+,LVEF,E/A and CO in the myocardial injury group were significantly lower than those in the non-myocardial injury group(P＜0.05),while the levels of CD4+,CD4+/CD8+,TSP-1,CK-MB,H-FABP,NT-proBNP and cTnⅠ were significantly higher than those in the non-myocardial injury group(P＜0.05).The peripheral blood CD8+level in sepsis patients with myocardial injury was negatively correlated with CK-MB,H-FABP,NT-proBNP and cTn Ⅰ(P＜0.05),and was positively correlated with LVEF,E/A and CO(P＜0.05).The levels of CD4+and CD4+/CD8+in peripheral blood were positively correlated with CK-MB,H-FABP,NT-proBNP and cTnⅠ(P＜0.05),and were negatively correlated with LVEF and E/A(P＜0.05).Serum TSP-1 level was positively correlated with CK-MB,H-FABP,NT-proBNP and cTnⅠ(P＜0.05),and negatively correlated with LVEF,E/A and CO(P＜0.05).The AUC,sensitivity and specificity of serum TSP-1 for predicting sepsis with myocardial injury were 0.899(95％CI:0.854-0.944),80.00％and 87.40％.Conclusion There is a cer-tain association between lymphocyte surface antigen,TSP-1 level and myocardial injury in patients with sepsis,and TSP-1 is expected to be a biomarker for predicting myocardial injury in patients with sepsis.
NETL
NSTL
万方数据
