Analysis of application value of PCT,CRP,SAA,CRP/ALB,NLR,NLPR levels in patients with sepsis complicated and acute renal injury
Objective To explore the diagnostic value of procalcitonin(PCT),C reaction protein(CRP),serum amyloid A(SAA)CRP/albumin(ALB),NLR,NLPR in sepsis patients with acute renal injury(AKI).Methods Totally 125 patients with sepsis combined with acute kidney injury attended the Gansu Provincial Hospital of TCM between September 2020 and August 2023 were collected,and AKI staging was performed based on glomerular filtration rate.Among them,39 pa-tients were in stage Ⅰ,48 patients were in stage Ⅱ,and 38 patients were in stage Ⅲ;at the same time,100 patients with sepsis without acute kidney injury were selected to compare the levels of PCT,CRP,SAA,CRP/ALB,NLR,and NLPR between two groups of patients.The predictive value of PCT,CRP,SAA,CRP/ALB,NLR,and NLPR for sepsis patients with AKI was evaluated using the receiver operating characteristic(ROC)curve.Results There was no statistically sig-nificant difference in general data such as gender,age,BMI,APACHE Ⅱ score,and underlying diseases between the AKI group and the non AKI group(P＞0.05).There were statistically significant between PCT,CRP,SAA,Cys-C,NLR,NLPR,CRP/ALB of AKI patients and those of the non AKI group(P＜0.05).The ALB of AKI group patients was signifi-cantly lower than that of non AKI group and the difference was statistically significant(P＜0.05).Compared with AKI group patients at different stages,PCT,CRP,SAA,Cys-C,NLR,NLPR,CRP/ALB of stage Ⅱ patients were signifi-cantly higher than that of stage Ⅰ patients,and the difference was statistically significant(P＜0.05).Compared to that of the stage Ⅲ patients,the difference was statistically significant in the PCT,CRP,SAA,Cys-C,NLR,NLPR,CRP/ALB of stage Ⅱ patients(P＜0.05).However,the ALB of stage Ⅰ patients was significantly higher than that of stage Ⅱpatients,and that of stage Ⅱ patients was significantly higher than that of stage Ⅲ patients,and the difference were statis-tically significant(P＜0.05).The logistic regression analysis showed that PCT,SAA,NLR,NLPR,CRP/ALB were all independent risk factors for sepsis complicated with AKI.ROC curve analysis showed that the cutoff value of PCT was 5.605,and the area under the curve was 0.972;the cutoff value of CRP was 71.5,and the area under the curve was 0.840;the cutoff value of SAA was 150.6,and the area under the curve was 0.978;The cutoff value of ALB was 33.45,and the area under the curve was 0.871;the cutoff value of CYS-C was 2.955,and the area under the curve was 0.933;the cutoff value of ALB/CRP was 1.915,and the area under the curve was 0.867;the cut-off value of NLR was 14.875,and the area under the curve was 0.874;the cutoff value of NLPR was 12.975,and the area under the curve was 0.837(P＜0.05).Conclusion PCT,CRP,SAA,CRP/ALB,NLR,NLPR have good predictive value for sepsis complicated with AKI.
SepsisProcalcitoninC-reactive protein to albumin ratioNeutrophil to lymphocyte ratioRatio of neutro-phil count to lymphocyte and platelet countAcute renal injury
NETL
NSTL
万方数据
