Effect of nasal double level positive pressure surfactant pulmonary on respiratory neonatal distress syndrome with combined ventilation and its effect on oxygenation
Objective To explore the efficacy and oxygenation effects of nasal positive pressure ventilation in Neonatal pa-tients with respiratory distress syndrome(NRDS)using pulmonary surfactant combined with neonatal positive pressure.Methods A retrospective analysis was conducted from August 2021 to October 2023A total of 136 children with NRDS admit-ted to the First People's Hospital of Pingdingshan were enrolled.On the basis of conventional treatment,the control group was treated with transnasal bi-level positive-pressure ventilation,and the observation group was treated with lung surface active substances.Observed and compared the blood gas index,respiratory function related index and oxygenation index of the two groups after treatment.Results The levels of PaCO2,PaO2 and SaO2 before treatment were compared between the two groups.The difference was not statistically significant(P＞0.05).The levels of PaO2 and SaO2 in the observation group after treatment were(86.35±5.68)mmHg and(95.62±2.64)mmHg,which were higher than those in the control group,and the differences were statistically significant(P＜0.05).The PaCO2 level of the control group was(36.97±4.03)mmHg,which was lower than(41.19±4.22)mmHg of the control group,and the difference was statistically significant(P＜0.05).There were no statistically significant differences in MAP,PIP and PEEP levels between the two groups before treatment(P＞0.05).The levels of MAP,PIP and PEEP in the observation group after treatment were(8.33±1.24)cmH2 0,(17.14±2.73)cmH2O and(4.22±0.70)cmH2O,which were lower than those in the control group,and the differences were sta-tistically significant(P＜0.05);In terms of oxygenation function,the oxygenation index of the observation group(268.41±15.62)mmHg was higher than that of the control group(200.07±14.24)mmHg,and the difference was statistically signifi-cant(P＜0.05).Conclusion For neonates with NRDS,pulmonary surfactant combined with nasal bi-level positive pres-sure ventilation can significantly improve oxygenation function and has a high clinical value.
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