Study on role of HPV E6/E7 mRNA combined with age in screening HPV-DNA positive shunt for cervical cancer
Objective Shunt effect of HPV E6/E7 mRNA combined age in cervical cancer screening for HPV-DNA positivity.Methods A total of 1,980 cases who had a sexual life history and requested cervical lesion screening were selected from January 2020 to January 2023 and visited the Affiliated Zhengzhou Central Hospital of Zhengzhou Universi-ty.All of them underwent three primary screenings including thinprep cytology test(TCT),HPV-DNA and HPV E6/E7 mRNA.And 584 cases with high-risk factors among them underwent cervical tissue biopsy under colposcopy.Tak-ing the pathological results as the diagnostic criteria,the differences in the positive rates of HPV E6/E7 mRNA and HPV-DNA in different age groups,the comparison of the positive detection rates of HPV-DNA and HPV E6/E7 mR-NA in different pathological grades,and the incidence of cervical diseases in different age groups were analyzed and compared.Results Among the 1980 cases,346 cases were HPV-DNA positive,with a total positive rate of 17.47％.The highest HPV-DNA infection rate was 69.39％in the 20-29 years old group,followed by the group over 60 years old,the positive rate was 68.57％.In the same age group,the positive rate of HPV E6/E7 mRNA in primary screening was lower than that of HPV-DNA,and the difference in detection rate between the two groups in each age group was statistically significant(P＜0.05).In chronic inflammation and LSIL lesions,the positive rate of HPV E6/E7 mRNA was lower than that of HPV-DNA,with statistical significance.With the upgrading of cervical lesions,The positive rate of HPV E6/E7 mRNA showed a gradual increase,and the difference was found to be statistically significant(P＜0.05).The risk of HSIL and cancer was lower in young women,but the degree of cervical lesions gradually escala-ted with the grow older,The disparity exhibited statistical significance(P＜0.05).Conclusion Attaching importance to age factor,combined with HPV E6/E7 mRNA,patients with HPV-DNA preliminary screening positive were shunted,and personalized clinical intervention programs were developed.
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