Effect of gene-guided antihypertensive drug selection on curative effect and PI3K/AKT signaling pathway in patients with hypertension
Objective To explore the application effect of gene detection of antihypertensive drugs in hypertension based on PI3K/AKT signaling pathway.Methods In this study,160 patients with hypertension who visited our hospital from January,2022 to May,2024 were selected as the observation objects.They were divided into genome(n=80)and control group(n=80)according to whether they accepted the hypertension gene test,and were given different antihypertensive drugs according to the test results,and the control group was given routine antihypertensive treatment.The adverse reactions and therapeutic effects of the two groups were observed,and the blood pressure control level,quality of life,endothelial function and PI3K/AKT signaling pathway were compared before and after treatment.Results The effect of genome therapy was better,and the risk of adverse reactions was lower(all P＜0.05).After treatment,the diastolic blood pressure,systolic blood pressure,ser-um ET-1 and PI3K/AKT signaling pathway related indicators(PI3K,AKT,B-cell lymphoma gene-2 and Bcl-2 related X protein)were lower than those of the control group(all P＜0.05),and the serum NO,FMD level,and life quality score were higher than those of the control group(all P＜0.05).Conclusion Gene detection of antihypertensive drugs can guide the clinical formulation of a more reasonable antihypertensive plan,thus achieving a better antihypertensive effect and signifi-cantly lowering the level of TLR4/NF-κB inflammatory signaling pathway.
TLR4/NF-κB signal pathwayAntihypertensive drugsGenetic testingHypertension
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