Application value of continuous renal replacement therapy combined with restricted fluid resuscitation in treatment of severe acute pancreatitis
Objective To investigate the application value of continuous renal replacement therapy(CRRT)combined with restricted fluid resuscitation in the treatment of severe acute pancreatitis(SAP).Methods In this prospective study,192 SAP patients admitted to the First Affiliated Hospital of Zhengzhou University from February 2020 to November 2023 were ran-domly divided into the control group and the study group.The control group received restricted fluid resuscitation therapy,and the study group received CRRT therapy on the basis of the control group to compare the efficacy.Results The total effective rate of the study group was 95.83％higher than that of the control group 77.08％(P＜0.05).The levels of serum amylase(AMS),lipase(LIPA)and lactate dehydrogenase(LDH)in 2 groups before treatment were compared(P＞0.05).The lev-els of AMS,LIPA and LDH in the study group were(153.58±14.56)U/L,(264.52±25.43)U/L and(183.42±18.95)U/L,respectively,which were lower than those in the control group(P＜0.05).CRP,IL-7 and MCP-1 were compared between the two groups before treatment(P＞0.05).The levels of C-reactive protein(CRP),interleukin-7(IL-7)and monocyte chemokine-1(MCP-1)in the study group were(76.12±16.13)mg/L,(37.21±3.42)ng/L and(20.14±3.02)pg/mL,respectively.It was lower than group control(P＜0.05).During the period treatment,the rate of complication the group study was 8.33％lower than group control 29.17％(P＜0.05).Conclusion CRRT combined with restricted fluid resuscitation in the treatment of SAP has obvious effects,can improve pancreatic function,reduce inflammation,and is safe,worthy of clinical promotion.
Severe acute pancreatitisContinuous renal replacement therapyRestricted fluid resuscitationInflammation
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