Effects of Idebenquinone combined with Pingchan Shujin decoction on oxidative stress index and dopamine function index in patients with Parkinson's disease
Objective To investigate the efficacy of Idebenone(IDE)in combination with Pingchan Shujin decoction in patients with Parkinson's disease(PD),including the effects on oxidative stress and dopamine function.Methods 98 patients with PD,who were admitted to the Affiliated Hospital of Henan Yellow River Institute of Science and Technology from 2021.1 to 2023.12,were randomly divided into a control group and a combination group,with 49 patients in each group.The patients were divided into control group and combined group by random grouping,and each group consisted of 49 cases.The patients of control group was treated with idebenone,while the combined group was combined with Pingchan Shujin decoction based on the control group.Comparing the symptom integration and adverse reactions of the two groups,montreal cognitive assessment(MoC A)before and after treatment,oxidative stress index level[superoxide dismutase(SOD),8-Hydroxydeoxyguanosinicacid(8-OHdG)and malondialdehyde(MDA)]and the level of dopa-mine function(dopamine entropy value,left caudate dopamine,left putamen dopamine,right caudate dopamine,and right putamen dopamine).Results After treatment,the symptom integral in combined group(11.88±1.54),8-OHdG(38.55±4.13)and MDA(7.54±0.83)were lower than those in the control group,The difference was statisti-cally significant(P＜0.05);MoCA(21.69±2.62)in the combined group,The difference was statistically significant(P＜0.05);In the combined group,dopamine entropy(4.33±0.42),left caudate dopamine(1.69±0.52),right caudate dopamine(1.64±0.52),left putamen dopamine(2.09±0.52)and right putamen dopamine(2.17±0.72)were higher than those in the control group;And there was no significant difference in the occurrence of adverse reac-tions between the two groups(P＞0.05).Conclusion IDE combined with Pingchan Shujin Decoction can improve ox-idative stress in PD patients,enhance dopamine function indicators,increase therapeutic efficacy,and has high safety.
IdebenonePingchanshujin decoctionParkinson's diseaseOxidative stressDopamine function
NETL
NSTL
万方数据
