Clinical observation on the treatment of children with allergic purpura by Xijiao Dihuang decoction and study on the risk factors of recurrent children
Objective To explore the clinical efficacy of Xijiao Dihuang decoction in the treatment of allergic purpura in children,and analyze the risk factors affecting the recurrence of the disease in children.Methods A total of 90 pa-tients who received treatment for allergic purpura in Xinyang Central Hospital from September 2022 to June 2024 were retrospectively selected.These patients were treated with Xijiao Dihuang decoction.According to whether allergic purpu-ra recurred or not,they were divided into the recurrence group(47 cases)and the non-recurrence group(43 cases).The general information,clinical manifestations and laboratory test results of the children in the two groups were com-pared.Univariate analysis was first carried out for each major influencing factor,and then multivariate logistic regression analysis was performed for the significant factors.Results After treatment,the total effective rate was significant,with 51 effective effects,32 effective and 7 ineffective,with a total effective rate of 92.22％.After follow-up,the recur-rence rate was 50.00％at 6 months and 52.22％within 12 months.The patients who were followed up for 12 months were divided into recurrence group and recurrence group according to whether they had recurrence,and univariate analy-sis showed that age,urine protein positivity rate,ALB,TG,CHOL,APTT,IgG,and IgA were the influencing factors for recurrence.Age,monocytes,IgG,and food intolerance were independent risk factors for recurrence during the follow-up period.When included in the logistic regression analysis,age,monocytes,LDH,IgG,PLT,MPV,food intolerance and positive urine protein are all independent risk factors for recurrence during the follow-up period of children,with Y=0.185 x age+monocytes+0.115 x LDH+0.351 x IgG+0.187 x PLT+0.266 x MPV+2.133 x food intolerance+2.451 x positive for proteinuria.Conclusion Xijiao Dihuang decoction has a high effective rate in the treatment of chil-dren with Henoch-Schonlein purpura,but the recurrence rate of patients with this disease is high within the follow-up year,and the recurrence factors are age,monocytes,lactate dehydrogenase(LDH),immunoglobulin G(IgG),plate-lets(PLT),average platelet volume(MPV),food intolerance and positive urine protein.
Henoch-Schonlein purpura in childrenXijiao Dihuang decoctionRecurrenceRisk factors
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