Correlation analysis of serum lipoprotein-associated phospholipase A2 and homocysteine in patients with acute cerebral infarction
Objective To investigate the relationship between lipoprotein-associated phospholipase a 2(lp-pla 2),homocysteine acid(Hey)and acute cerebral infarction(ACI).Methods Totally 192 patients with ACI from January 2021 to December2021 were 2023 into three groups:Group A(mild defect),Group B(moderate defect),and Group C(severe defect)according to the National Institutes of Health Stroke Scale(NIHSS),the levels of Lp-PLA2 and Hcy were compared among 64 subjects in each group and 64 healthy subjects in the same period as Group D,three months after discharge,the patients with acute cerebral infarction were divided into two groups according to the modified Rankin Scale(mRS),the levels of Lp-PLA2 and Hcy were compared and ROC curves were drawn to analyze the prognostic value of Lp-PLA2 and Hcy in patients with ACI.Results In terms of Lp-PLA2 and Hcy levels,group A[(297.85±94.49)μg/L,(25.42±8.73)μmol/L],group B[(246.49±81.25)μg/L,(21.49±6.21)μmol/L],and group C[(205.84±76.42)μg/L,(18.59±5.28)μmol/L]were higher than D group[(25.42±8.73)μmol/L,P＜0.05][(170.46±60.79)μg/L,(14.97±5.24)μmol/L](P＜0.05).The levels of Lp-PLA2 and Hey in group A and group B were higher than those in group C(P＜0.05).The levels of Lp-PLA2 and Hcy in group A were higher than those in group B(P＜0.05).At 3 months after discharge,there were 156 cases with good prognosis and 36 cases with poor prognosis in ACI patients.There was no significant difference in gender,age and BMI between the two groups(P＞0.05).The levels of Lp-PLA2 and Hcy in patients with poor prognosis were(315.45±90.25)μg/L and(23.63±8.79)μmol/L,respectively,which were higher than those in patients with good prognosis(P＜0.05).The correlation analysis of NIHSS score showed that Hcy level was positively correlated with NIHSS score in ACI patients(r=0.437,P＜0.05).Lp-PLA2 level was positively correlated with NIHSS score in ACI patients(r=0.462,P＜0.05).The ROC curve of Lp-PLA2,Hey and their combination for predicting the prognosis of ACI patients was drawn,and the results showed that the area under the curve(AUC)was 0.734(95％CI:0.584-0.891),0.786(95％CI:0.681-0.846),0.803(95％CI:0.539-0.846).Conclusion The levels of Hey and Lp-PLA2 are closely related to the neurological deficits and the development of the disease in patients with acute cerebral infarction,and they are of great value in judging the prognosis of the disease.
Lipoprotein-associated phospholipase A2HomocysteineAcute cerebral infarctionNeurological function
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