Randomized controlled clinical observation on treatment of bronchiolitis obliterans in children with Qi Yin deficiency and phlegm stasis syndrome after infection with Yangfei Tongluo Formula
Objective To observe the clinical efficacy of Yangfei Tongluo Formula combined with conventional Western medicine methods in treating children with bronchiolitis obliterans caused by Qi Yin deficiency and phlegm stasis syn-drome infection,and to explore its possible mechanism of action.Methods Totally 63 children with post infectious bronchiolitis obliterans admitted to the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from December 1,2021 to May 31,2023 were randomly divided into a treatment group of 32 cases and a control group of 31 cases.The control group was treated with conventional Western medicine methods,while the treatment group received an additional treatment of lung nourishing and meridian unblocking formula on the basis of the control group.Both groups were treated for 3 months.Compared the clinical symp-tom scores,tidal lung function,tidal volume(Tidal Volume/kg),time to peak ratio(TPTEF/TE),volume to peak ratio(VPEF/VE),and serum levels of interleukin-6(IL-6),interleukin-8(IL-8),matrix metalloproteinase 9(MMP-9),tissue inhibitor of matrix metalloproteinase 1(TIMP-1),and matrix metalloproteinase 9/tissue inhibitor of matrix metalloproteinase 1(MMP-9/TIMP-1)before and after treatment in two groups of children,and evaluated the clinical efficacy after treatment.Results After treatment,the clinical symptom scores,IL-6,IL-8,MMP-9,MMP-9/TIMP-1 levels of both groups of children decreased compared to before treatment(P＜0.05),while the lev-el of TIMP-1 showed no significant change compared to before treatment(P＞0.05).After treatment,the clinical symptom score,IL-6,IL-8,and MMP-9 levels in the treatment group were lower than those in the control group(P＜0.05).Both groups of patients showed normal tidal volume and decreased TPTEF/TE and VPEF/VE in tidal lung function.Neither treatment regimen improved the obstructive ventilation dysfunction of the patients.The total effective rate of the treatment group was 83.33％(25/30),while the total effective rate of the control group was 58.06％(18/31).The clinical efficacy of the treatment group was better than that of the control group(P＜0.05).Conclusion The combination of Yangfei Tongluo Formula and conventional Western medicine treatment can significantly improve the clin-ical symptoms of children with Qi Yin deficiency and phlegm stasis syndrome,and the efficacy is better than that of con-ventional Western medicine treatment alone.The mechanism may be related to the downregulation of IL-6,IL-8,and MMP-9/TIMP-1 levels.
Post infection bronchiolitis obliteransYangfei Tongluo FormulaQi and Yin deficiency combined with phlegm and blood stasisInflammatory factors
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