Analyze the current situation and risk factors of sarcopenia in patients with liver cirrhosis and develop countermeasures
Objective To analyze the current situation and influence factor of sarcopenia in patients with liver cirrho-sis,and to develop intervention measures based on this.Methods Selection of clinical data from 114 patients with liver cirrhosis admitted from July 2022 to December 2023.According to the occurrence of sarcopenia,patients were divided into sarcopenia group and non sarcopenia group.The baseline data and laboratory indicators of two groups were cpmpared;using logistic regression to analyze the influencing factors of sarcopenia in patients with liver cirrhosis;con-struct a column chart model based on the results of binary logistic regression analysis and conduct internal validation.Results Among 114 patients with cirrhosis,46 cases developed sarcopenia,with a sarcopenia incidence rate of 40.35％;the BMI,upper arm circumference,lower leg circumference,ALB was lower than that of the non sarcopenia group,and the proportion of males with ascites was higher than that of the non sarcopenia group(P＜0.05);accord-ing to logistic regression analysis,male and ascites are influence factors for sarcopenia in patients with liver cirrhosis(OR＞1,P＜0.05),while BMI and ALB were protective factors(OR＜1,P＜0.05).Based on the above influen-cing factors,a column chart model was constructed and validated using the Bootstrap internal validation method.The C-index value was 0.927,and the receiver operating characteristic(ROC)curve was plotted for internal validation.The results showed that the AUC of the column chart model for predicting muscle atrophy in patients with cirrhosis was 0.927(95％confidence interval:0.877-0.978,P＜0.001),which has a certain predictive value;the specificity,sensitivity,and Youden index were 0.912,0.870,and 0.782,respectively.Conclusion The incidence of sarcopenia in patients with liver cirrhosis is relatively high.BMI,gender,ALB,and ascites are risk factors for sar-copenia in patients with liver cirrhosis,and they have certain value in predicting the occurrence of sarcopenia in pa-tients with liver cirrhosis.Medical staff can take targeted measures to prevent or reduce the risk of sarcopenia in pa-tients with liver cirrhosis through the above influencing factors.
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