Analysis of different follow-up intervals associated clinical characteristics of urban and rural children with postural tachycardia syndrome
Objective To explore the different follow-up intervals associated clinical characteristics of the urban and rural children with postural tachycardia syndrome.Methods There were 91 children,with syncope or symptoms of pres-yncope,aged 4-16 years old[(10±2.3)years old]who were diagnosed with POTS by head-up tilt test in our clinics or hospital were selected,the children were divided into the urban group(total 43cases,males 25 cases,females 18 ca-ses)and the rural group(total 48 cases,males 21 cases,females 27 cases),they were all given basic therapies and(or medical therapy),its follow-up period was 1-17 months(M 4 months),comparing the follow-up intervals between the urban and the rural children with POTS and efficiencies within 3 months were used to assess their short-term cura-tive effect,the trial is taken as invalid as the endpoint event,Kaplan-Meier survival analysis was done to evaluate the long-term cumulative effective rate of the urban and rural children with POTS.Results The follow-up interval for the rural children with POTS was 3 months(M25=2 months,M75=5.5 months),while that for the urban children was 1 month(M25=2 months,M75=5.5months),the follow-up interval for the urban children with POTS was shorter than that for the rural children(Z=-4.132,P＜0.001);after 3 months of treatment and at the end of the trial,the symptom scores of the two groups of treated children with POTS significantly were decreased,among them,the scores of the urban group were obviously lower(P=0.04);further analysis of the relationship between the follow-up interval and efficacy,the median and interval follow-up interval between the effective and invalid groups after 3 months of treatment was 2 months(M25=1 month,M75=3 months),6months(M25=3 months,M75=6 months)(Z=-5.368,P＜0.001),at the end of follow-up,it was 2 months(M25=1 month,M75=3 months),6 months(M25=3 months,M75=6 months),(Z=-2.654,P=0.008＜0.05).Long-term efficacy:Kaplan-Meier survival analysis was done to evaluate the long-term cumulative effective rate of urban and rural children with POTS,it showed that the cumulative response rate of urban children with POTS was significantly higher than that in the rural children,moreover,the urban children with POTS had fewer episodes of syncope or aura of the syncope.Conclusion The follow-up interval of the urban children with POTS was shorter than that of the rural children with POTS,simultaneously,the follow-up interval in the treatment-effective group was also shorter than that in the ineffective group.
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